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The role of CRH in placental biology : studies employing a choriocarcinoma cell line
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Delidaki, Maria (2011) The role of CRH in placental biology : studies employing a choriocarcinoma cell line. PhD thesis, University of Warwick.
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Official URL: http://webcat.warwick.ac.uk/record=b2662166~S1
Abstract
The hypothalamic component of HPA–axis CRH is also produced by the placenta and it
has been postulated to control a “placental clock” during pregnancy which determines
the onset of parturition. However, the role of CRH in early trophoblast biology is
currently unknown. In this thesis we investigated the role of CRH/CRH receptor in early
placentation using the fusigenic choriocarcinoma cell line BeWo.
These cells expressed functional CRH-R coupled to MAPK signalling cascades. In this
cellular model, CRH was shown to promote survival and to induce cell proliferation,
however in the presence of differentiation-inducing signals (such as forskolin) CRH
further augmented up-regulation of fusogenic gene expression and hCG secretion
induced by forskolin. Therefore, placental CRH appears to influence placenta biology.
Finally, it was shown for the first time that CRH actions were sensitive to TLR4
activation raising the possibility that the innate immune system is an important regulator
of placental CRH biological actions.
Item Type: | Thesis (PhD) | ||||
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Subjects: | Q Science > QP Physiology | ||||
Library of Congress Subject Headings (LCSH): | Corticotropin releasing hormone, Placenta, Choriocarcinoma, Cell lines | ||||
Official Date: | January 2011 | ||||
Dates: |
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Institution: | University of Warwick | ||||
Theses Department: | Warwick Medical School | ||||
Thesis Type: | PhD | ||||
Publication Status: | Unpublished | ||||
Supervisor(s)/Advisor: | Grammatopoulos, Dimitris | ||||
Sponsors: | University of Warwick | ||||
Extent: | xxi, 245 leaves : illustrations, charts. | ||||
Language: | eng |
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