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Exploration of the medical periodic table : towards new targets
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Barry, Nicolas P. E. and Sadler, P. J. (2013) Exploration of the medical periodic table : towards new targets. Chemical Communications, Volume 49 (Number 45). pp. 5106-5131. doi:10.1039/c3cc41143e ISSN 1359-7345.
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Official URL: http://dx.doi.org/10.1039/C3CC41143E
Abstract
Metallodrugs offer potential for unique mechanisms of drug action based on the choice of the metal, its oxidation state, the types and number of coordinated ligands and the coordination geometry. We discuss recent progress in identifying new target sites and elucidating the mechanisms of action of anti-cancer, anti-bacterial, anti-viral, anti-parasitic, anti-inflammatory, and anti-neurodegenerative agents, as well as in the design of metal-based diagnostic agents. Progress in identifying and defining target sites has been accelerated recently by advances in proteomics, genomics and metal speciation analysis. Examples of metal compounds and chelating agents (enzyme inhibitors) currently in clinical use, clinical trials or preclinical development are highlighted.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Journal or Publication Title: | Chemical Communications | ||||
Publisher: | Royal Society of Chemistry | ||||
ISSN: | 1359-7345 | ||||
Official Date: | 1 May 2013 | ||||
Dates: |
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Volume: | Volume 49 | ||||
Number: | Number 45 | ||||
Page Range: | pp. 5106-5131 | ||||
DOI: | 10.1039/c3cc41143e | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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