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Statistical mechanics models for X-chromosome inactivation
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Scialdone, Antonio and Nicodemi, Mario (2010) Statistical mechanics models for X-chromosome inactivation. Advances in Complex Systems, Vol.13 (No.3). pp. 367-376. doi:10.1142/S0219525910002566 ISSN 0219-5259.
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Official URL: http://dx.doi.org/10.1142/S0219525910002566
Abstract
We present statistical mechanics models to understand the physical and molecular mechanisms of X-Chromosome Inactivation (XCI), the process whereby a female mammal cell inactivates one of its two X-chromosomes. During XCI, X-chromosomes undergo a series of complex regulatory processes. At the beginning of XCI, the X's recognize and pair, then only one X which is randomly chosen is inactivated. Afterwards, the two X's move to different positions in the cell nucleus according to their different status (active/silenced). Our models illustrate about the still mysterious physical bases underlying all these regulatory steps, i.e., X-chromosome pairing, random choice of inactive X, and "shuttling" of the X's to their post-XCI locations. Our models are based on general and robust thermodynamic roots, and their validity can go beyond XCI, to explain analogous regulatory mechanisms in a variety of cellular processes.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QA Mathematics Q Science |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||
Journal or Publication Title: | Advances in Complex Systems | ||||
Publisher: | World Scientific Publishing Company PTE Ltd | ||||
ISSN: | 0219-5259 | ||||
Official Date: | June 2010 | ||||
Dates: |
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Volume: | Vol.13 | ||||
Number: | No.3 | ||||
Number of Pages: | 10 | ||||
Page Range: | pp. 367-376 | ||||
DOI: | 10.1142/S0219525910002566 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
Data sourced from Thomson Reuters' Web of Knowledge
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