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Hepatic triacylglycerol synthesis and secretion : DGAT2 as the link between glycaemia and triglyceridaemia
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Zammit, Victor A. (2013) Hepatic triacylglycerol synthesis and secretion : DGAT2 as the link between glycaemia and triglyceridaemia. Biochemical Journal, Volume 451 (Number 1). pp. 1-12. doi:10.1042/BJ20121689 ISSN 0264-6021.
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Official URL: http://dx.doi.org/10.1042/BJ20121689
Abstract
The liver regulates both glycaemia and triglyceridaemia. Hyperglycaemia and hypertriglyceridaemia are both characteristic of (pre)diabetes. Recent observations on the specialised role of DGAT2 (diacylglycerol acyltransferase 2) in catalysing the de novo synthesis of triacylglycerols from newly synthesized fatty acids and nascent diacylglycerols identifies this enzyme as the link between the two. This places DGAT2 at the centre of carbohydrate-induced hypertriglyceridaemia and hepatic steatosis. This function is complemented, but not substituted for, by the ability of DGAT1 to rescue partial glycerides from complete hydrolysis. In peripheral tissues not normally considered to be lipogenic, synthesis of triacylglycerols may largely bypass DGAT2 except in hyperglycaemic/hyperinsulinaemic conditions, when induction of de novo fatty acid synthesis in these tissues may contribute towards increased triacylglycerol secretion (intestine) or insulin resistance (adipose tissue, and cardiac and skeletal muscle).
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Biochemical Journal | ||||
| Publisher: | Portland Press | ||||
| ISSN: | 0264-6021 | ||||
| Official Date: | 1 April 2013 | ||||
| Dates: |
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| Volume: | Volume 451 | ||||
| Number: | Number 1 | ||||
| Page Range: | pp. 1-12 | ||||
| DOI: | 10.1042/BJ20121689 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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