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Mathematical model of bursting in dissociated Purkinje neurons
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Forrest, Michael D. (2013) Mathematical model of bursting in dissociated Purkinje neurons. PLoS One, Volume 8 (Number 8). e68765. doi:10.1371/journal.pone.0068765 ISSN 1932-6203.
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WRAP_Forrest_journal.pone.0068765.pdf - Published Version Available under License Creative Commons Attribution. Download (837Kb) | Preview |
Official URL: http://dx.doi.org/10.1371/journal.pone.0068765
Abstract
In vitro, Purkinje cell behaviour is sometimes studied in a dissociated soma preparation in which the dendritic projection has been cleaved. A fraction of these dissociated somas spontaneously burst. The mechanism of this bursting is incompletely understood. We have constructed a biophysical Purkinje soma model, guided and constrained by experimental reports in the literature, that can replicate the somatically driven bursting pattern and which hypothesises Persistent Na+ current (INaP) to be its burst initiator and SK K+ current (ISK) to be its burst terminator.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QA Mathematics Q Science > QH Natural history > QH301 Biology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | ||||
Library of Congress Subject Headings (LCSH): | Purkinje cells , Purkinje cells -- Research, Neurons -- Mathematical models | ||||
Journal or Publication Title: | PLoS One | ||||
Publisher: | Public Library of Science | ||||
ISSN: | 1932-6203 | ||||
Official Date: | 13 August 2013 | ||||
Dates: |
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Volume: | Volume 8 | ||||
Number: | Number 8 | ||||
Page Range: | e68765 | ||||
DOI: | 10.1371/journal.pone.0068765 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 25 December 2015 | ||||
Date of first compliant Open Access: | 25 December 2015 | ||||
Funder: | Medical Research Council (Great Britain) (MRC) |
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