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Heart rate variability and target organ damage in hypertensive patients
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Melillo, Paolo, Izzo, Raffaele, De Luca, Nicola and Pecchia, Leandro (2012) Heart rate variability and target organ damage in hypertensive patients. BMC Cardiovascular Disorders, Volume 12 (Number 1). Article number 105. doi:10.1186/1471-2261-12-105 ISSN 1471-2261.
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Official URL: http://dx.doi.org/10.1186/1471-2261-12-105
Abstract
Background:
We evaluated the association between linear standard Heart Rate Variability (HRV) measures and vascular, renal and cardiac target organ damage (TOD).
Methods:
A retrospective analysis was performed including 200 patients registered in the Regione Campania network (aged 62.4 ± 12, male 64%). HRV analysis was performed by 24-h holter ECG. Renal damage was assessed by estimated glomerular filtration rate (eGFR), vascular damage by carotid intima-media thickness (IMT), and cardiac damage by left ventricular mass index.
Results:
Significantly lower values of the ratio of low to high frequency power (LF/HF) were found in the patients with moderate or severe eGFR (p-value < 0.001). Similarly, depressed values of indexes of the overall autonomic modulation on heart were found in patients with plaque compared to those with a normal IMT (p-value <0.05). These associations remained significant after adjustment for other factors known to contribute to the development of target organ damage, such as age. Moreover, depressed LF/HF was found also in patients with left ventricular hypertrophy but this association was not significant after adjustment for other factors.
Conclusions:
Depressed HRV appeared to be associated with vascular and renal TOD, suggesting the involvement of autonomic imbalance in the TOD. However, as the mechanisms by which abnormal autonomic balance may lead to TOD, and, particularly, to renal organ damage are not clearly known, further prospective studies with longitudinal design are needed to determine the association between HRV and the development of TOD.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > R Medicine (General) | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||
Library of Congress Subject Headings (LCSH): | Heart rate, Hypertension, Target organs (Anatomy), Multiple organ failure | ||||
Journal or Publication Title: | BMC Cardiovascular Disorders | ||||
Publisher: | BioMed Central Ltd. | ||||
ISSN: | 1471-2261 | ||||
Official Date: | 2012 | ||||
Dates: |
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Volume: | Volume 12 | ||||
Number: | Number 1 | ||||
Page Range: | Article number 105 | ||||
DOI: | 10.1186/1471-2261-12-105 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 25 December 2015 | ||||
Date of first compliant Open Access: | 25 December 2015 | ||||
Funder: | Campania (Italy), Università di Napoli, Italy. Ministero dell'istruzione, dell'università e della ricerca (MIUR) , Engineering and Physical Sciences Research Council (EPSRC) | ||||
Grant number: | EP/F063822/1 (EPSRC) |
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