Guo, Shuixia, Kendrick, Keith M., Zhang, Jie, Broome, Matthew R., Yu, Rongjun, Liu, Zhening and Feng, Jianfeng (2013) Brain-wide functional inter-hemispheric disconnection is a potential biomarker for schizophrenia and distinguishes it from depression. NeuroImage: Clinical, Volume 2 . pp. 818-826. doi:10.1016/j.nicl.2013.06.008 ISSN 2213-1582.

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Abstract

Schizophrenia is associated with disconnectivity in the brain although it is still unclear whether changes within or between hemispheres are of greatest importance. In this paper, an analysis of 152 schizophrenia patients compared with 122 healthy controls was carried out. Comparisons were also made with 39 depression patients and 37 controls to examine whether brain-wide changes in inter- or intra-hemispheric functional connectivity are most associated with the disorder and can distinguish it from depression. The authors developed new techniques (first and second order symmetry) to investigate brain-wide changes in patients (45 regions per hemisphere) and their association with illness duration and symptom severity. Functional connectivity between the same regions in left- and right-hemispheres (first order symmetry) was significantly reduced as was that between the same pairs of regions in the left- and right-hemispheres (second order symmetry) or using all possible inter-hemispheric connections in schizophrenia patients. By contrast, no significant changes were found for brain-wide intra-hemispheric links. First order symmetry changes correlated significantly with positive and negative symptom severity for functional connections linked via the anterior commissure and negative symptoms for those linked via the corpus callosum. Support vector machine analysis revealed that inter-hemispheric symmetry changes had 73–81% accuracy in discriminating schizophrenia patients and either healthy controls or depressed patients. In conclusion, reduced brain-wide inter-hemispheric functional connectivity occurs in schizophrenia, is associated with symptom severity, and can discriminate schizophrenia patients from depressed ones or healthy controls. Brain-wide changes in inter-hemispheric connections may therefore provide a useful potential biomarker for schizophrenia.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	Faculty of Science, Engineering and Medicine > Science > Computer Science Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Schizophrenia, Psychoses , Depression, Mental , Depression, Mental -- Diagnosis, Clinical trials, Clinical medicine -- Research
Journal or Publication Title:	NeuroImage: Clinical
Publisher:	Elsevier BV
ISSN:	2213-1582
Official Date:	2013
Dates:	Date Event 2013 Published
Volume:	Volume 2
Page Range:	pp. 818-826
DOI:	10.1016/j.nicl.2013.06.008
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Date of first compliant deposit:	25 December 2015
Date of first compliant Open Access:	25 December 2015
Funder:	Royal Society (Great Britain). Wolfson Research Merit Award (RSWRMA), Zhongguo ke xue yuan [Chinese Academy of Sciences] (CAS), Guo jia zi ran ke xue ji jin wei yuan hui (China) [National Natural Science Foundation of China] (NSFC) , Hunan Provincial Education Department (HPED)
Grant number:	11271121, 91132720 (NSFC) ; 11K038 (HPED)

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