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Human papillomavirus infections and upper aero-digestive tract cancers : the ARCAGE Study
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(2013) Human papillomavirus infections and upper aero-digestive tract cancers : the ARCAGE Study. JNCI Journal of the National Cancer Institute, Volume 105 (Number 8). pp. 536-545. doi:10.1093/jnci/djt053 ISSN 0027-8874.
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Official URL: http://dx.doi.org/10.1093/jnci/djt053
Abstract
Human papillomavirus (HPV) is causally implicated in a subset of cancers of the upper aero-digestive tract
(UADT).
Methods Associations between type-specific HPV antibodies were examined among 1496 UADT cancer case subjects and
1425 control subjects by estimating odds ratios (ORs) in logistic regression analyses adjusted for potential confounders. The agreement between serology and tumor markers of HPV infection, including presence of HPV DNA
and p16 expression, were examined in a subset of tumors.
Results HPV16 L1 seropositivity was associated with increased risk of oral cavity and oropharyngeal cancer (OR = 1.94, 95%
confidence interval [CI] = 1.03 to 3.65; OR = 8.60, 95% CI = 5.21 to 14.20, respectively). HPV16 E6 antibodies were
present in 30.2% of oropharyngeal case subjects and only 0.8% of control subjects (OR = 132.0, 95% CI = 65.29 to
266.86). Combined seropositivity to HPV16 E6 and E7 was rare (n = 1 of 1425 control subjects). An agreement of
67% was observed between HPV16 E6 serology and the corresponding presence of an HPV-related cancer: four
of six HPV DNA-positive/p16-overexpressing tumors were HPV16 E6 antibody positive. An HPV16 independent
association was observed for HPV18 and oropharyngeal cancer (OR = 8.14, 95% CI = 2.21 to 29.99 for HPV18 E6
seropositivity) and HPV6 and laryngeal cancer (OR = 3.25, 95% CI = 1.46 to 7.24 for HPV6 E7 seropositivity).
Conclusions These results confirm an important role for HPV16 infection in oropharyngeal cancer. HPV16 E6 antibodies are
strongly associated with HPV16-related oropharyngeal cancers. Continuing efforts are needed to consider both
HPV serology and p16 staining as biomarkers relevant to the etiology and natural history of HPV16-related oropharyngeal tumors. These results also support a marginal role for HPV18 in oropharyngeal cancer and HPV6 in
laryngeal cancer
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Journal or Publication Title: | JNCI Journal of the National Cancer Institute | ||||
Publisher: | Oxford University Press | ||||
ISSN: | 0027-8874 | ||||
Official Date: | 2013 | ||||
Dates: |
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Volume: | Volume 105 | ||||
Number: | Number 8 | ||||
Page Range: | pp. 536-545 | ||||
DOI: | 10.1093/jnci/djt053 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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