The Library
The binary oral dysplasia grading system : validity testing and suggested improvement
Tools
Nankivell, Paul, Williams, Hazel, Matthews, Paul, Suortamo, Sari, Snead, David R. J., McConkey, Christopher C. and Mehanna, Hisham M. (2013) The binary oral dysplasia grading system : validity testing and suggested improvement. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 115 (Number 1). pp. 87-94. doi:10.1016/j.oooo.2012.10.015 ISSN 2212-4403.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1016/j.oooo.2012.10.015
Abstract
Objectives: A binary system is reputed to be superior to the World Health Organization (WHO) system in grading oral dysplasia. We aimed to validate its reproducibility and prognostic ability and examine whether it could be improved.
Study Design: Three pathologists graded 141 oral epithelial dysplasia biopsies with the use of both systems. Observer variability and prognostic ability were assessed with the use of kappa and logistic regression models.
Results: The binary system showed superior agreement to the WHO system (multirater kappa 0.59 vs. 0.49, respectively) but similar prognostic ability (odds ratio [OR] 4.59 [P = .014] vs. OR 2.25 [P = .02], respectively). Adding smoking and alcohol slightly improved the prognostic ability of both systems (OR 5.10 vs. OR 2.42, respectively). Our new binary system with a refined diagnostic threshold demonstrated a slightly greater prognostic ability and improved ability to differentiate between high- and low-risk moderate dysplasia cases.
Conclusions: The binary system has similar prognostic ability but superior reproducibility compared with the WHO system. Prognostication is improved still further by using a new threshold.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Journal or Publication Title: | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology | ||||
Publisher: | Mosby, Inc. | ||||
ISSN: | 2212-4403 | ||||
Official Date: | January 2013 | ||||
Dates: |
|
||||
Volume: | Volume 115 | ||||
Number: | Number 1 | ||||
Page Range: | pp. 87-94 | ||||
DOI: | 10.1016/j.oooo.2012.10.015 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |