The Library
Enhanced susceptibility to superantigen‐associated streptococcal sepsis in human leukocyte antigen–DQ transgenic mice
Tools
Sriskandan, Shiranee, Unnikrishnan, Meera, Krausz, Thomas, Dewchand, Hamlata, Van Noorden, Susan, Cohen, Jonathan and Altmann, Daniel M. (2001) Enhanced susceptibility to superantigen‐associated streptococcal sepsis in human leukocyte antigen–DQ transgenic mice. The Journal of Infectious Diseases, Volume 184 (Number 2). pp. 166-173. doi:10.1086/322018 ISSN 0022-1899.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1086/322018
Abstract
Bacterial superantigens are believed to cause septic shock, although, because of the lack of superantigen-sensitive infection models, proof that superantigenicity underlies shock pathogenesis is lacking. This work demonstrates a clear superantigen effect in septic shock resulting from bacterial infection. Transgenic expression of human leukocyte antigen (HLA)–DQ, but not HLA-DR, specifically augments lymphocyte responses to streptococcal pyrogenic exotoxin A (SPEA). HLA-DQ transgenic mice had increased mortality after administration of SPEA or infection with Streptococcus pyogenes. Immune activation during infection was HLA-DQ transgene–dependent and was manifested by Vβ-specific T cell repertoire changes and widespread lymphoblastic tissue infiltration. Unlike earlier models, which used toxin-induced shock, these T cell superantigen responses and lymphoblastoid changes were observed during invasive streptococcal sepsis. Lymphoid activation was undetectable in HLA-DQ mice infected with an isogenic SPEA− strain, which proves that a single superantigen can play a role in sepsis pathogenesis
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QR Microbiology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||
Library of Congress Subject Headings (LCSH): | Superantigens, Bacterial antigens, Streptococcal infections -- Susceptibility, HLA histocompatibility antigens, Transgenic mice | ||||
Journal or Publication Title: | The Journal of Infectious Diseases | ||||
Publisher: | Oxford University Press | ||||
ISSN: | 0022-1899 | ||||
Official Date: | July 2001 | ||||
Dates: |
|
||||
Volume: | Volume 184 | ||||
Number: | Number 2 | ||||
Page Range: | pp. 166-173 | ||||
DOI: | 10.1086/322018 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | Medical Research Council (Great Britain) (MRC) |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |