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Revised radiobiological modelling of the contribution of synchronous chemotherapy to the rate of grades 3-4 mucositis in head and neck cancer
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Meade, Sara, McConkey, Christopher C., Sanghera, Paul, Mehanna, Hisham M. and Hartley, Andrew (2013) Revised radiobiological modelling of the contribution of synchronous chemotherapy to the rate of grades 3-4 mucositis in head and neck cancer. Journal of Medical Imaging and Radiation Oncology, Volume 57 (Number 6). pp. 733-738. doi:10.1111/1754-9485.12096 ISSN 1754-9477.
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Official URL: http://dx.doi.org/10.1111/1754-9485.12096
Abstract
Introduction
Biological effective dose (BED) calculations modelled on reduced accelerated repopulation when synchronous chemotherapy is delivered significantly correlate with observed differences in local control in randomised trials of platinum-based chemoradiation. The purpose of this study was to examine whether a similar relationship existed in the context of grades 3–4 mucositis.
Methods
Biological effective dose from radiotherapy and synchronous chemotherapy was calculated using three different models: AB using the additional BED attributable to chemotherapy and standard repopulation parameters; zero repopulation (ZRP) using zero correction for repopulation; and variable tp (Vtp) using a variable doubling time for mucosal stem cell repopulation. The correlation between the percentage change in biological effective dose between trial arms, and the observed percentage change in the rate of grades 3–4 mucositis was examined by using the Pearson product–moment correlation.
Results
With the AB model, there were no significant correlations with observed differences in rates of grades 3–4 mucositis. With either the ZRP or Vtp models, significant correlations were observed. A value of 5 days for the doubling time during repopulation (Tp) was associated with the most significant correlation (P = 0.002).
Conclusion
Models where the dose lost due to accelerated repopulation is reduced imply a therapeutic loss from the use of synchronous chemotherapy when only local control and the rate of acute grades 3–4 mucositis are considered.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Journal of Medical Imaging and Radiation Oncology | ||||
Publisher: | Wiley-Blackwell Publishing Asia | ||||
ISSN: | 1754-9477 | ||||
Official Date: | 2013 | ||||
Dates: |
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Volume: | Volume 57 | ||||
Number: | Number 6 | ||||
Page Range: | pp. 733-738 | ||||
DOI: | 10.1111/1754-9485.12096 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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