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Nonautonomous movement of chromosomes in mitosis
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Vladimirou, Elina , Mchedlishvili, Nunu, Gasic, Ivana, Armond, Jonathan W., Samora, Catarina P., Meraldi, Patrick and McAinsh, Andrew D. (2013) Nonautonomous movement of chromosomes in mitosis. Developmental Cell, Volume 27 (Number 1). pp. 60-71. doi:10.1016/j.devcel.2013.08.004 ISSN 1534-5807.
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Official URL: http://dx.doi.org/10.1016/j.devcel.2013.08.004
Abstract
Kinetochores are the central force-generating machines that move chromosomes during cell division. It is generally assumed that kinetochores move in an autonomous manner. However, we reveal here that movements of neighboring sister-kinetochore pairs in metaphase are correlated in a distance-dependent manner. This correlation increases in the absence of kinetochore oscillations or stable end-on attachments. This suggests that periodic movements of bioriented chromosomes limit the correlated motion of nonsisters. Computer simulations show that these correlated movements can occur when elastic crosslinks are placed between the K-fibers of oscillating kinetochores. Strikingly, inhibition of the microtubule crosslinking motor kinesin-5 Eg5 leads to an increase in nonsister correlation and impairs periodic oscillations. These phenotypes are partially rescued by codepletion of the kinesin-12 Kif15, demonstrating a function for kinesin-5 and kinesin-12 motors in driving chromosome movements, possibly as part of a crosslinking structure that correlates the movements of nonsister kinetochores.
| Item Type: | Journal Article | ||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Developmental Cell | ||||
| Publisher: | Cell Press | ||||
| ISSN: | 1534-5807 | ||||
| Official Date: | 14 October 2013 | ||||
| Dates: |
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| Volume: | Volume 27 | ||||
| Number: | Number 1 | ||||
| Page Range: | pp. 60-71 | ||||
| DOI: | 10.1016/j.devcel.2013.08.004 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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