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The role of hepcidin-25 in kidney transplantation
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Chan, W., G. Ward, Douglas, McClean, Andrew, A. Bosch, Jos, Jones, David, Kaur, Okdeed, Drayson, Mark, Whitelegg, Alison, Iqbal, Tariq, McTernan, P. G. (Philip G.), Tselepis, Chris and Borrows, Richard (2013) The role of hepcidin-25 in kidney transplantation. Transplantation Journal, Volume 95 (Number 11). pp. 1390-1395. doi:10.1097/TP.0b013e31828d8489 ISSN 0041-1337.
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Official URL: http://dx.doi.org/10.1097/TP.0b013e31828d8489
Abstract
Background: Hepcidin-25 is a peptide hormone involved in iron absorption and homeostasis and found at increased serum levels in conditions involving systemic inflammation, renal dysfunction, and increased adiposity. Hepcidin may play a role in the pathogenesis of anemia, but its role in kidney transplantation is undefined. Methods: This study enrolled 100 stable patients beyond 12 months after transplantation, from a large single United Kingdom center. Serum hepcidin-25 level, and relevant demographic and laboratory data pertinent to posttransplantation anemia, were measured and collected. Independent predictors of serum hepcidin were evaluated, and the relationship between hepcidin and hemoglobin, assessed. Results: Independent associations were seen between higher hepcidin levels and allograft dysfunction (estimated glomerular filtration rate), increased inflammation (high-sensitivity C-reactive peptide), higher transferrin saturation (a marker of iron stores), and the use of marrow-suppressive medication (P<0.05 for all). Higher fat tissue index (whole-body multifrequency bioimpedance measurement) was also associated with higher hepcidin levels, but this relationship did not persist after adjustment for inflammation (high-sensitivity C-reactive peptide). In turn, inflammation was associated with increased fat tissue index (P=0.01) and male gender (P=0.04). A nonlinear association between serum hepcidin level and hemoglobin was seen, with a progressive fall in hemoglobin as hepcidin levels rose to 100 ng/mL, but little effect thereafter (P=0.009). This association was independent of renal dysfunction and female gender, both of which were also independently associated with a lower hemoglobin level. Conclusions: These results highlight possible mechanisms of hemoglobin reduction in kidney transplantation patients, and the therapeutic opportunities from understanding the role of hepcidin in this context.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Transplantation Journal | ||||
| Publisher: | Lippincott Williams & Wilkins | ||||
| ISSN: | 0041-1337 | ||||
| Official Date: | 15 June 2013 | ||||
| Dates: |
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| Volume: | Volume 95 | ||||
| Number: | Number 11 | ||||
| Page Range: | pp. 1390-1395 | ||||
| DOI: | 10.1097/TP.0b013e31828d8489 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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