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Pictet–Spengler reactions of oxetan-3-ones and related heterocycles
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Beasley, Benjamin O., Alli-Balogun, Abimbola, Clarkson, Guy J. and Shipman, Michael (2014) Pictet–Spengler reactions of oxetan-3-ones and related heterocycles. Tetrahedron Letters, Volume 55 (Number 2). pp. 541-543. doi:10.1016/j.tetlet.2013.11.077 ISSN 0040-4039.
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Official URL: http://dx.doi.org/10.1016/j.tetlet.2013.11.077
Abstract
Pictet–Spengler reactions of oxetan-3-ones and azetidin-3-ones with tryptamine and tryptophan derivatives produce spirocyclic tetrahydro-β-carbolines in good yields. Molecular iodine (5 mol %) is an effective catalyst in most cases and high levels of diastereoselectivity are witnessed using 2-substituted oxetan-3-ones.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Journal or Publication Title: | Tetrahedron Letters | ||||
Publisher: | Elsevier | ||||
ISSN: | 0040-4039 | ||||
Official Date: | 2014 | ||||
Dates: |
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Volume: | Volume 55 | ||||
Number: | Number 2 | ||||
Page Range: | pp. 541-543 | ||||
DOI: | 10.1016/j.tetlet.2013.11.077 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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