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Modification of ibuprofen drug release from poly(ethylene glycol) layered silicate nanocomposites prepared by hot-melt extrusion
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Campbell, Kayleen T., Craig, Duncan Q. M. and McNally, Tony (2014) Modification of ibuprofen drug release from poly(ethylene glycol) layered silicate nanocomposites prepared by hot-melt extrusion. Journal of Applied Polymer Science, Volume 131 (Number 10). Article number 40284. doi:10.1002/app.40284 ISSN 0021-8995.
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Official URL: http://dx.doi.org/10.1002/app.40284
Abstract
Composites of the poorly water soluble drug ibuprofen, a nonsteroidal anti-inflammatory commonly used for pain relief, with layered silicates (nanoclays) and a poly(ethylene glycol) (PEG) were prepared by hot melt extrusion. A highly intercalated and partially exfoliated morphology was determined using wide-angle x-ray diffraction, field emission scanning electron microscopy, and high-resolution transmission electron microscopy. The crystalline content of PEG was significantly reduced, as shown by differential scanning calorimetry studies, as a consequence of the large surface area of clay platelets physically hindering polymer chain dynamics and, in the case of montmorillonite, by tethering of PEG via hydrogen bonding. Addition of layered silicate retarded the release of ibuprofen from the PEG matrix, even though the crystalline content of PEG was reduced. This study therefore indicates that drug release in solid dispersion systems may be modified or indeed tailored by the inclusion of layered silicates. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40284.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) | ||||
Journal or Publication Title: | Journal of Applied Polymer Science | ||||
Publisher: | John Wiley & Sons, Inc. | ||||
ISSN: | 0021-8995 | ||||
Official Date: | May 2014 | ||||
Dates: |
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Volume: | Volume 131 | ||||
Number: | Number 10 | ||||
Article Number: | Article number 40284 | ||||
DOI: | 10.1002/app.40284 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) |
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