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Serum homocysteine concentration is related to diabetes mellitus, but not to coronary heart disease, in Saudi Arabians
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Al-Nozah, M., Al-Daghri, Nasser M., Bartlett, W. A., Al-Attas, O., Al-Maatouq, M., Martin, S. C., Kumar, Sudhesh and Jones, A. F. (2002) Serum homocysteine concentration is related to diabetes mellitus, but not to coronary heart disease, in Saudi Arabians. Diabetes, Obesity and Metabolism, Volume 4 (Number 2). pp. 118-123. doi:10.1046/j.1463-1326.2002.00191.x ISSN 1462-8902.
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Official URL: http://dx.doi.org/10.1046/j.1463-1326.2002.00191.x
Abstract
Introduction: Plasma homocysteine (HCYS) concentration is believed to be an independent risk factor for atherosclerosis.
Methods: HCYS was measured in a cohort of 584 Saudi Arabians participating in a national screening study of coronary heart disease (CHD) risk factors. A total of 173 subjects (114 men and 59 women) had clinical CHD, of whom 82 (47.4%) had type 2 diabetes mellitus (56 men and 26 women). A further 127 subjects (60 men and 67 women) also had type 2 diabetes mellitus but no CHD. A total of 284 individuals (120 men and 164 women) were recruited as healthy controls, and had no previous history of CHD or diabetes. Serum HCYS was measured by high-performance liquid chromatography (HPLC) with electrochemical detection.
Results: Univariate analysis showed HCYS concentrations were significantly lower in those with diabetes mellitus (DM) than in controls, for both men [8.7 (4.2–18.6) vs. 10.5 (4.5–20.5) mmol/l, median (5th−95th percentiles, p = 0.009] and women [6.3 (3.3–24.0) vs. 8.1 (4.0–17.9) mmol/l, p = 0.049]. Stepwise multivariate regression analysis indicated a relationship between HCYS concentration and age, sex and the presence of DM, but not with CHD.
Conclusions: In the Saudi Arabian population, serum HCYS is not a risk factor for CHD, but is lower in patients with DM.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Journal or Publication Title: | Diabetes, Obesity and Metabolism | ||||
Publisher: | Blackwell | ||||
ISSN: | 1462-8902 | ||||
Official Date: | 2002 | ||||
Dates: |
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Volume: | Volume 4 | ||||
Number: | Number 2 | ||||
Page Range: | pp. 118-123 | ||||
DOI: | 10.1046/j.1463-1326.2002.00191.x | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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