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Diagnostic metagenomics : potential applications to bacterial, viral and parasitic infections
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Pallen, Mark J. (2014) Diagnostic metagenomics : potential applications to bacterial, viral and parasitic infections. Parasitology , Volume 141 (Number 14). pp. 1856-1862. doi:10.1017/S0031182014000134 ISSN 0031-1820.
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Official URL: http://dx.doi.org/10.1017/S0031182014000134
Abstract
The term 'shotgun metagenomics' is applied to the direct sequencing of DNA extracted from a sample without culture or target-specific amplification or capture. In diagnostic metagenomics, this approach is applied to clinical samples in the hope of detecting and characterizing pathogens. Here, I provide a conceptual overview, before reviewing several recent promising proof-of-principle applications of metagenomics in virus discovery, analysis of outbreaks and detection of pathogens in contemporary and historical samples. I also evaluate future prospects for diagnostic metagenomics in the light of relentless improvements in sequencing technologies.
Item Type: | Journal Article | ||||||||||
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Subjects: | Q Science > QH Natural history | ||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Metagenomics, Diagnosis | ||||||||||
Journal or Publication Title: | Parasitology | ||||||||||
Publisher: | Cambridge University Press | ||||||||||
ISSN: | 0031-1820 | ||||||||||
Official Date: | December 2014 | ||||||||||
Dates: |
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Volume: | Volume 141 | ||||||||||
Number: | Number 14 | ||||||||||
Number of Pages: | 7 | ||||||||||
Page Range: | pp. 1856-1862 | ||||||||||
DOI: | 10.1017/S0031182014000134 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
Date of first compliant deposit: | 27 December 2015 | ||||||||||
Date of first compliant Open Access: | 27 December 2015 |
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