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The coverage and frequency of mass drug administration required to eliminate persistent transmission of soil-transmitted helminths
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Anderson, Roy M., Truscott, James E. and Hollingsworth, T. Déirdre (2014) The coverage and frequency of mass drug administration required to eliminate persistent transmission of soil-transmitted helminths. Philosophical Transactions of the Royal Society B, Volume 369 (Number 1645). Article number 20130435. doi:10.1098/rstb.2013.0435
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Official URL: http://dx.doi.org/10.1098/rstb.2013.0435
Abstract
A combination of methods, including mathematical model construction, demographic plus epidemiological data analysis and parameter estimation, are used to examine whether mass drug administration (MDA) alone can eliminate the transmission of soil-transmitted helminths (STHs). Numerical analyses suggest that in all but low transmission settings (as defined by the magnitude of the basic reproductive number, R0), the treatment of pre-school-aged children (pre-SAC) and school-aged children (SAC) is unlikely to drive transmission to a level where the parasites cannot persist. High levels of coverage (defined as the fraction of an age group effectively treated) are required in pre-SAC, SAC and adults, if MDA is to drive the parasite below the breakpoint under which transmission is eliminated. Long-term solutions to controlling helminth infections lie in concomitantly improving the quality of the water supply, sanitation and hygiene (WASH). MDA, however, is a very cost-effective tool in long-term control given that most drugs are donated free by the pharmaceutical industry for poor regions of the world. WASH interventions, by lowering the basic reproductive number, can facilitate the ability of MDA to interrupt transmission.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QA Mathematics R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Science > Mathematics |
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| Library of Congress Subject Headings (LCSH): | Helminthiasis -- Prevention, Helminthiasis -- Chemotherapy, Helminthiasis -- Mathematical models, Soilborne infection -- Prevention | ||||
| Journal or Publication Title: | Philosophical Transactions of the Royal Society B | ||||
| Publisher: | The Royal Society | ||||
| Official Date: | 12 May 2014 | ||||
| Dates: |
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| Volume: | Volume 369 | ||||
| Number: | Number 1645 | ||||
| Number of Pages: | 14 | ||||
| Article Number: | Article number 20130435 | ||||
| DOI: | 10.1098/rstb.2013.0435 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||
| Date of first compliant deposit: | 27 December 2015 | ||||
| Date of first compliant Open Access: | 27 December 2015 | ||||
| Funder: | Bill & Melinda Gates Foundation, Wellcome Trust (London, England) | ||||
| Grant number: | 097830/Z/11/A-C (WT) |
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