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Prospects for novel inhibitors of peptidoglycan transglycosylase
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Galley, Nicola F., O'Reilly, Amy M. and Roper, David I. (2014) Prospects for novel inhibitors of peptidoglycan transglycosylase. Bioorganic Chemistry, Volume 55 (Number 100). pp. 16-26. doi:10.1016/j.bioorg.2014.05.007 ISSN 0045-2068.
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Official URL: http://dx.doi.org/10.1016/j.bioorg.2014.05.007
Abstract
The lack of novel antimicrobial drugs under development coupled with the increasing occurrence of resistance to existing drugs by community and hospital acquired infections is of grave concern. The biosynthesis of the bacterial cell wall has provided a rich vein of antimicrobial targets in the past but relatively little development has been directed toward the transglycosylase step of this process. In this article, we review the assay methods developed for the key enzymes involved and review recent novel chemical inhibitors discovered in relation to both the lipidic substrates and natural product inhibitors of the transglycosylase step.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QR Microbiology | ||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
| Library of Congress Subject Headings (LCSH): | Glycosyltransferases, Anti-infective agents | ||||||
| Journal or Publication Title: | Bioorganic Chemistry | ||||||
| Publisher: | Academic Press | ||||||
| ISSN: | 0045-2068 | ||||||
| Official Date: | August 2014 | ||||||
| Dates: |
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| Volume: | Volume 55 | ||||||
| Number: | Number 100 | ||||||
| Number of Pages: | 29 | ||||||
| Page Range: | pp. 16-26 | ||||||
| DOI: | 10.1016/j.bioorg.2014.05.007 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 27 December 2015 | ||||||
| Date of first compliant Open Access: | 27 December 2015 | ||||||
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Engineering and Physical Sciences Research Council (EPSRC) |
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