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Can chemotherapy alone eliminate the transmission of soil transmitted helminths?
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Truscott, James E., Hollingsworth, T. Déirdre, Brooker, Simon J. and Anderson, Roy M. (2014) Can chemotherapy alone eliminate the transmission of soil transmitted helminths? Parasites and Vectors, Volume 7 . Article number 266. doi:10.1186/1756-3305-7-266
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Official URL: http://dx.doi.org/10.1186/1756-3305-7-266
Abstract
Background: Amongst the world's poorest populations, availability of anthelmintic treatments for the control of soil transmitted helminths (STH) by mass or targeted chemotherapy has increased dramatically in recent years. However, the design of community based treatment programmes to achieve the greatest impact on transmission is still open to debate. Questions include: who should be treated, how often should they be treated, how long should treatment be continued for?
Methods: Simulation and analysis of a dynamic transmission model and novel data analyses, suggest refinements of the World Health Organization guidelines for the community based treatment of STH.
Results: This analysis shows that treatment levels and frequency must be much higher, and the breadth of coverage across age classes broader than is typically the current practice, if transmission is to be interrupted by mass chemotherapy alone.
Conclusions: When planning interventions to reduce transmission, rather than purely to reduce morbidity, current school-based interventions are unlikely to be enough to achieve the desired results.
| Item Type: | Journal Article | ||||||||
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| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Science > Mathematics |
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| Library of Congress Subject Headings (LCSH): | Helminths -- Chemotherapy, Public health -- Developing countries | ||||||||
| Journal or Publication Title: | Parasites and Vectors | ||||||||
| Publisher: | BioMed Central | ||||||||
| Official Date: | 10 June 2014 | ||||||||
| Dates: |
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| Volume: | Volume 7 | ||||||||
| Article Number: | Article number 266 | ||||||||
| DOI: | 10.1186/1756-3305-7-266 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 27 December 2015 | ||||||||
| Date of first compliant Open Access: | 27 December 2015 | ||||||||
| Funder: | Bill & Melinda Gates Foundation, Imperial College London. Partnership for Child Development, Wellcome Trust (London, England) | ||||||||
| Grant number: | OPP1033751 (BMGF), 098045 (WT), 097830/Z/11/A-C (WT) |
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