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Sensitivities, specificities, and predictive values of microbiological culture techniques for the diagnosis of prosthetic joint infection
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Jordan, Robert W., Smith, Nicholas A., Saithna, Adnan, Sprowson, Andrew P. and Foguet, Pedro (2014) Sensitivities, specificities, and predictive values of microbiological culture techniques for the diagnosis of prosthetic joint infection. BioMed Research International, Volume 2014 . pp. 1-5. Article number 180416. doi:10.1155/2014/180416 ISSN 2314-6133.
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Official URL: http://dx.doi.org/10.1155/2014/180416
Abstract
Background. Identifying the microorganism in a prosthetic joint infection is the key to appropriately targeting antimicrobial treatment. Despite the availability of various techniques, no single test is considered the definitive gold standard. Aim. Our aim was to determine the sensitivity, specificity, and positive/negative predictive values for a variety of culture techniques. Methods. We performed a retrospective case series of 219 patients undergoing revision surgery of their hip or knee replacement between May 2004 and February 2013. The patients were classified as either infected or noninfected according to criteria set out by the Musculoskeletal Infection Society. The number and type of samples taken intraoperatively varied between cases but included tissue samples and fluid sent in either blood culture vials or sterile containers. Results. The highest sensitivity was found with blood culture vials (0.85) compared to fluid in sterile containers (0.26) and tissues samples (0.32). Blood culture vials also had a better specificity and positive and negative predictive values profile. Conclusion. We conclude that, of the techniques studied, fluid in blood culture vials had the best profile for the correct identification of microorganisms and advocate its use.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QR Microbiology R Medicine > RD Surgery R Medicine > RM Therapeutics. Pharmacology |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Artificial joints -- Infections, Anti-infective agents, Microbiology -- Technique, Microbiology -- Cultures and culture media | ||||||||
Journal or Publication Title: | BioMed Research International | ||||||||
Publisher: | Hindawi Publishing Corporation | ||||||||
ISSN: | 2314-6133 | ||||||||
Official Date: | 25 May 2014 | ||||||||
Dates: |
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Volume: | Volume 2014 | ||||||||
Page Range: | pp. 1-5 | ||||||||
Article Number: | Article number 180416 | ||||||||
DOI: | 10.1155/2014/180416 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 27 December 2015 | ||||||||
Date of first compliant Open Access: | 27 December 2015 |
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