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Characterisation of anaphylaxis in a large UK city with an ethnically diverse population
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Buka, Richard J., Crossman, Richard, Derbridge, Cathryn, Huissoon, Aarnoud P., Hackett, Scott, Cooke, Matthew (Professor of clinical systems design), Dorrian, Susan and Krishna, Mamidipudi T. (2014) Characterisation of anaphylaxis in a large UK city with an ethnically diverse population. Journal of Allergy and Clinical Immunology , Volume 133 (Number 2). Article number AB23. doi:10.1016/j.jaci.2013.12.109 ISSN 0091-6749.
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Official URL: http://dx.doi.org/10.1016/j.jaci.2013.12.109
Abstract
RATIONALE: Little is known about anaphylaxis in the non-white
population (NWP). Birmingham is the second largest city in UK with an
ethnically diverse population; 42% are ‘non-white’ as opposed to an
overall proportion of 15% in England. East Birmingham is a relatively
deprived area with a high density of NWP (50%).
METHODS: We retrospectively applied the World Allergy Organisation
(WAO) diagnostic criteria to patients admitted to our emergency
department in 2012.
RESULTS: Annual incidence of anaphylaxis in this population is
approximately 8.8 per 10000. 220 attendances fulfilled the WAO criteria,
mean age 32.5 (6 22.4 SD). 53 (24%) were <_ 16 years and 88 (40%) were
male. 97 (44%) were caucasian, 99 (45%) were south asian, and 24 (11%)
had other ethnic origins. Incidence of anaphylaxis was 10.4/10000 and
8.2/10000 in the South Asian and Caucasian population respectively.
98 (44.5%) cases were graded as severe, 13 (5.9%) developed a biphasic
response and there was one fatality. Patients with a history of atopy were
more likely to develop a severe episode (p50.0074). Acute serum
tryptase was measured in 79 cases and was raised in 22 giving a
sensitivity of 25%. The main aetiology in those attending follow-up was
food in children [n527(93.1%)] as opposed to idiopathic in adults
[n542(67.7%)].
CONCLUSIONS: The overall incidence of anaphylaxis was modestly
greater than previously reported in other countries, and seems a significant
problem in NWP of east Birmingham. Whilst food was the main trigger in
children conforming to previous reports, idiopathic anaphylaxis was the
commonest aetiology in adults
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Journal of Allergy and Clinical Immunology | ||||
Publisher: | Mosby, Inc. | ||||
ISSN: | 0091-6749 | ||||
Official Date: | February 2014 | ||||
Dates: |
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Volume: | Volume 133 | ||||
Number: | Number 2 | ||||
Article Number: | Article number AB23 | ||||
DOI: | 10.1016/j.jaci.2013.12.109 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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