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Guidance for laboratories performing molecular pathology for cancer patients
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Cree, Ian A., Deans, Zandra, Ligtenberg, Marjolijn J. L., Normanno, Nicola, Edsjo, Anders, Rouleau, Etienne, Sole, Francesc, Thunnissen, Eriq, Timens, Wim, Schuuring, Ed, Dequeker, Elisabeth, Murray, Samuel, Dietel, Manfred, Groenen, Patricia and Van Krieken, J. Han (2014) Guidance for laboratories performing molecular pathology for cancer patients. Journal of Clinical Pathology, Volume 67 . pp. 923-931. doi:10.1136/jclinpath-2014-202404 ISSN 0021-9746.
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WRAP_Cree_J Clin Pathol-2014-Cree-jclinpath-2014-202404.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial. Download (560Kb) | Preview |
Official URL: http://dx.doi.org/10.1136/jclinpath-2014-202404
Abstract
Molecular testing is becoming an important part of the diagnosis of any patient with cancer. The challenge to laboratories is to meet this need, using reliable methods and processes to ensure that patients receive a timely and accurate report on which their treatment will be based. The aim of this paper is to provide minimum requirements for the management of molecular pathology laboratories. This general guidance should be augmented by the specific guidance available for different tumour types and tests. Preanalytical considerations are important, and careful consideration of the way in which specimens are obtained and reach the laboratory is necessary. Sample receipt and handling follow standard operating procedures, but some alterations may be necessary if molecular testing is to be performed, for instance to control tissue fixation. DNA and RNA extraction can be standardised and should be checked for quality and quantity of output on a regular basis. The choice of analytical method(s) depends on clinical requirements, desired turnaround time, and expertise available. Internal quality control, regular internal audit of the whole testing process, laboratory accreditation, and continual participation in external quality assessment schemes are prerequisites for delivery of a reliable service. A molecular pathology report should accurately convey the information the clinician needs to treat the patient with sufficient information to allow for correct interpretation of the result. Molecular pathology is developing rapidly, and further detailed evidence-based recommendations are required for many of the topics covered here.
Item Type: | Journal Article | ||||||||
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Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RB Pathology R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Cancer -- Molecular diagnosis -- Laboratory manuals, Cancer -- Patients -- Care, Molecular diagnosis, Genetic screening | ||||||||
Journal or Publication Title: | Journal of Clinical Pathology | ||||||||
Publisher: | B M J Group | ||||||||
ISSN: | 0021-9746 | ||||||||
Official Date: | 10 July 2014 | ||||||||
Dates: |
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Volume: | Volume 67 | ||||||||
Page Range: | pp. 923-931 | ||||||||
DOI: | 10.1136/jclinpath-2014-202404 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 27 December 2015 | ||||||||
Date of first compliant Open Access: | 27 December 2015 |
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