The Library
Analytical applications of ion activation techniques
Tools
Jennings, Keith R. (2015) Analytical applications of ion activation techniques. International Journal of Mass Spectrometry, 377 . pp. 610-616. doi:10.1016/j.ijms.2014.05.017 ISSN 1387-3806.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1016/j.ijms.2014.05.017
Abstract
Since the first experiments in which high energy collision induced decomposition was used to determine structural information nearly fifty years ago, a variety of different methods of ion activation have been developed each of which has its own advantages and disadvantages. The development of โsoftโ ionisation techniques and their use to ionise biological species of very high molecular weights has resulted in ion activation techniques and tandem mass spectrometry becoming one of the most important fields of interest. Developments in mass analysers have also changed the emphasis placed on different activation techniques and opened up new opportunities and challenges.
Although collision induced decomposition (CID) has been widely used, it has a number of drawbacks and new ion activation methods have been developed, the most widely used being electron capture decomposition (ECD) and electron transfer decomposition (ETD), each of which has its own particular advantages. Surface induced decomposition (SID) has been less widely adopted because it requires commercial instrumentation to be modified. Applications of these four techniques are discussed with special reference to peptide and protein sequencing.
Item Type: | Journal Article | ||||||||
---|---|---|---|---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
Journal or Publication Title: | International Journal of Mass Spectrometry | ||||||||
Publisher: | Elsevier BV | ||||||||
ISSN: | 1387-3806 | ||||||||
Official Date: | 1 February 2015 | ||||||||
Dates: |
|
||||||||
Volume: | 377 | ||||||||
Page Range: | pp. 610-616 | ||||||||
DOI: | 10.1016/j.ijms.2014.05.017 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |