The Library
Influence of age, severity of infection, and co-infection on the duration of respiratory syncytial virus (RSV) shedding
Tools
Munywoki, Patrick Kiio, Koech, Dorothy C., Agoti, Charles N., Kibirige, N., Kipkoech, J., Cane, Patricia, Medley, Graham and Nokes, D. James (2015) Influence of age, severity of infection, and co-infection on the duration of respiratory syncytial virus (RSV) shedding. Epidemiology and Infection, 143 (4). pp. 804-812. doi:10.1017/S0950268814001393 ISSN 0950-2688.
|
PDF
WRAP_Medley_S0950268814001393a.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution. Download (483Kb) | Preview |
Official URL: http://dx.doi.org/10.1017/S0950268814001393
Abstract
RSV is the most important viral cause of pneumonia and bronchiolitis in children worldwide and has been associated with significant disease burden. With the renewed interest in RSV vaccines, we provide realistic estimates on duration, and influencing factors on RSV shedding which are required to better understand the impact of vaccination on the virus transmission dynamics. The data arise from a prospective study of 47 households (493 individuals) in rural Kenya, followed through a 6-month period of an RSV seasonal outbreak. Deep nasopharyngeal swabs were collected twice each week from all household members, irrespective of symptoms, and tested for RSV by multiplex PCR. The RSV G gene was sequenced. A total of 205 RSV infection episodes were detected in 179 individuals from 40 different households. The infection data were interval censored and assuming a random event time between observations, the average duration of virus shedding was 11·2 (95% confidence interval 10·1–12·3) days. The shedding durations were longer than previous estimates (3·9–7·4 days) based on immunofluorescence antigen detection or viral culture, and were shown to be strongly associated with age, severity of infection, and revealed potential interaction with other respiratory viruses. These findings are key to our understanding of the spread of this important virus and are relevant in the design of control programmes.
Item Type: | Journal Article | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Subjects: | Q Science > QR Microbiology > QR355 Virology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||
Library of Congress Subject Headings (LCSH): | Respiratory syncytial virus -- Kenya, Respiratory syncytial virus -- Transmission | ||||||||||
Journal or Publication Title: | Epidemiology and Infection | ||||||||||
Publisher: | Cambridge University Press | ||||||||||
ISSN: | 0950-2688 | ||||||||||
Official Date: | March 2015 | ||||||||||
Dates: |
|
||||||||||
Volume: | 143 | ||||||||||
Number: | 4 | ||||||||||
Page Range: | pp. 804-812 | ||||||||||
DOI: | 10.1017/S0950268814001393 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
Date of first compliant deposit: | 27 December 2015 | ||||||||||
Date of first compliant Open Access: | 27 December 2015 | ||||||||||
Funder: | Wellcome Trust (London, England) | ||||||||||
Grant number: | 090853 (WT), 084633 (WT) |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year