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A novel framework for exploratory analysis of highly variable morphology of migrating epithelial cells
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Jefferyes, Samuel, D. R., Epstein, D. B. A., Straube, Anne and Rajpoot, Nasir M. (Nasir Mahmood) (2013) A novel framework for exploratory analysis of highly variable morphology of migrating epithelial cells. In: 2013 35TH Annual International Conference of The IEEE Engineering in Medicine and Biology Society (EMBC), Osaka, 3-7 July 2013 pp. 3463-3466. doi:10.1109/EMBC.2013.6610287
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Official URL: http://dx.doi.org/10.1109/EMBC.2013.6610287
Abstract
Migratory cells, for example human retinal epithelial (RPE) cells, exhibit highly variable morphology. This makes it difficult to use traditional methods, such as the landmark based Procrustes analysis or feature based analysis, to quantitatively represent their shapes. We propose a novel framework to generate a low-dimensional representation of highly variable cell shapes. The framework lends itself readily to efficient exploratory analysis of a given cell shape dataset in order to visualise morphological trends in the data and reveal the intrinsic structure of various morphology-based cell phenotypes in the data. Preliminary results show that the framework is effective in revealing consistent morphological phenotypes.
| Item Type: | Conference Item (Paper) | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre | ||||
| Publisher: | IEEE Computer Society | ||||
| Book Title: | 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) | ||||
| Official Date: | 2013 | ||||
| Dates: |
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| Page Range: | pp. 3463-3466 | ||||
| DOI: | 10.1109/EMBC.2013.6610287 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Conference Paper Type: | Paper | ||||
| Title of Event: | 2013 35TH Annual International Conference of The IEEE Engineering in Medicine and Biology Society (EMBC) | ||||
| Type of Event: | Conference | ||||
| Location of Event: | Osaka | ||||
| Date(s) of Event: | 3-7 July 2013 |
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