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The yeast actin cytoskeleton
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Mishra, Mithilesh, Huang, Junqi and Balasubramanian, Mohan K. (2014) The yeast actin cytoskeleton. FEMS Microbiology Reviews, Volume 38 (Number 2). pp. 213-227. doi:10.1111/1574-6976.12064 ISSN 0168-6445.
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Official URL: http://dx.doi.org/10.1111/1574-6976.12064
Abstract
The actin cytoskeleton is a complex network of dynamic polymers, which plays an important role in various fundamental cellular processes, including maintenance of cell shape, polarity, cell division, cell migration, endocytosis, vesicular trafficking, and mechanosensation. Precise spatiotemporal assembly and disassembly of actin structures is regulated by the coordinated activity of about 100 highly conserved accessory proteins, which nucleate, elongate, cross-link, and sever actin filaments. Both in vivo studies in a wide range of organisms from yeast to metazoans and in vitro studies of purified proteins have helped shape the current understanding of actin dynamics and function. Molecular genetics, genome-wide functional analysis, sophisticated real-time imaging, and ultrastructural studies in concert with biochemical analysis have made yeast an attractive model to understand the actin cytoskeleton, its molecular dynamics, and physiological function. Studies of the yeast actin cytoskeleton have contributed substantially in defining the universal mechanism regulating actin assembly and disassembly in eukaryotes. Here, we review some of the important insights generated by the study of actin cytoskeleton in two important yeast models the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe.
Item Type: | Journal Article | ||||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Dean's Office & Professional Support Services Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | FEMS Microbiology Reviews | ||||||||||
Publisher: | John Wiley & Sons, Inc. | ||||||||||
ISSN: | 0168-6445 | ||||||||||
Official Date: | March 2014 | ||||||||||
Dates: |
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Volume: | Volume 38 | ||||||||||
Number: | Number 2 | ||||||||||
Page Range: | pp. 213-227 | ||||||||||
DOI: | 10.1111/1574-6976.12064 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access |
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