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A novel role for the adipokine visfatin/pre-B cell colony-enhancing factor 1 in prostate carcinogenesis
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Patel, Snehal T., Mistry, Tina, Brown, James E. P., Digby, Janet E., Adya, Raghu, Desai, Ken M. and Randeva, Harpal S. (2010) A novel role for the adipokine visfatin/pre-B cell colony-enhancing factor 1 in prostate carcinogenesis. Peptides, Vol.31 (No.1). pp. 51-57. doi:10.1016/j.peptides.2009.10.001 ISSN 0196-9781.
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Official URL: http://dx.doi.org/10.1016/j.peptides.2009.10.001
Abstract
Adipose tissue is now well established as an endocrine organ and multiple hormones termed 'adipokines' are released from it. With the rapidly increasing obese population and the increased risk mortality from prostate cancer within the obese population we looked to investigate the role of the adipokine visfatin in LNCaP and PC3 prostate cancer cell lines. Using immunohistochemistry and immunocytochemistry we demonstrate visfatin expression in LNCaP (androgen-sensitive) and PC3 (androgen-insensitive) human prostate cancer cell lines as well as human prostate cancer tissue. Additionally, we show that visfatin increases PC3 cell proliferation and demonstrate the activation of the MAPKs ERK-1/2 and p38. Moreover we also demonstrate that visfatin promotes the expression and activity of MMP-2/9 which are important proteases involved in the breakdown of the extracellular matrix, suggesting a possible role for visfatin in prostate cancer metastases. These data suggest a contributory and multifunctional role for visfatin in prostate cancer progression, with particular relevance and emphasis in an obese Population. (C) 2009 Elsevier Inc. All rights reserved.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Peptides | ||||
| Publisher: | Elsevier Inc | ||||
| ISSN: | 0196-9781 | ||||
| Official Date: | January 2010 | ||||
| Dates: |
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| Volume: | Vol.31 | ||||
| Number: | No.1 | ||||
| Number of Pages: | 7 | ||||
| Page Range: | pp. 51-57 | ||||
| DOI: | 10.1016/j.peptides.2009.10.001 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Ipsen Clinical Research Fund |
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