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The fault lies on the other side : altered brain functional connectivity in psychiatric disorders is mainly caused by counterpart regions in the oppposite hemisphere
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Zhang, J., Kendrick, K. M., Lu, G. and Feng, Jianfeng (2015) The fault lies on the other side : altered brain functional connectivity in psychiatric disorders is mainly caused by counterpart regions in the oppposite hemisphere. Cerebral Cortex, 25 (10). pp. 3475-3486. doi:10.1093/cercor/bhu173 ISSN 1047-3211.
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Official URL: http://dx.doi.org/10.1093/cercor/bhu173
Abstract
Many psychiatric disorders are associated with abnormal resting-state functional connectivity between pairs of brain regions, although it remains unclear whether the fault resides within the pair of regions themselves or other regions connected to them. Identifying the source of dysfunction is crucial for understanding the etiology of different disorders. Using pathway- and network-based techniques to analyze resting-state functional magnetic imaging data from a large population of patients with attention deficit hyperactivity disorder (239 patients, 251 controls), major depression (39 patients, 37 controls), and schizophrenia (69 patients, 62 controls), we show for the first time that only network-based cross-correlation identifies significant functional connectivity changes in all 3 disorders which survive correction. This demonstrates that the primary source of dysfunction resides not in the regional pairs themselves but in their external connections. Combining pathway and network-based functional-connectivity analysis, we established that, in all 3 disorders, the counterparts of pairs of regions in the opposite hemisphere contribute 60–76% to altered functional connectivity, compared with only 17–21% from the regions themselves. Thus, a transdiagnostic feature is of abnormal functional connectivity between brain regions produced via their contralateral counterparts. Our results demonstrate an important role for contralateral counterpart regions in contributing to altered regional connectivity in psychiatric disorders.
| Item Type: | Journal Article | ||||||
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| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | ||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | ||||||
| Library of Congress Subject Headings (LCSH): | Biological psychiatry, Neural transmission -- Disorders, Brain -- Research, Attention-deficit hyperactivity disorder, Depression, Mental, Schizophrenia | ||||||
| Journal or Publication Title: | Cerebral Cortex | ||||||
| Publisher: | Oxford University Press | ||||||
| ISSN: | 1047-3211 | ||||||
| Official Date: | 2015 | ||||||
| Dates: |
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| Volume: | 25 | ||||||
| Number: | 10 | ||||||
| Page Range: | pp. 3475-3486 | ||||||
| DOI: | 10.1093/cercor/bhu173 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||
| Date of first compliant deposit: | 4 March 2016 | ||||||
| Date of first compliant Open Access: | 4 March 2016 | ||||||
| Funder: | Guo jia zi ran ke xue ji jin wei yuan hui (China) [National Natural Science Foundation of China] (NSFC), Royal Society (Great Britain). Wolfson Research Merit Award (RSWRMA), Seventh Framework Programme (European Commission) (FP7), Engineering and Physical Sciences Research Council (EPSRC), Zhongguo ke xue yuan [Chinese Academy of Sciences] (CAS) | ||||||
| Grant number: | 61004104 and 6110414 (NSFC), BION (FP7), NCMIS (CAS) |
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