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Modelling of tumour growth and cytotoxic effect of docetaxel in xenografts
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Evans, Neil D., Dimelow, Richard and Yates, James W. T. (2014) Modelling of tumour growth and cytotoxic effect of docetaxel in xenografts. Computer Methods and Programs in Biomedicine, Volume 114 (Number 3). e3-e13. doi:10.1016/j.cmpb.2013.06.014 ISSN 0169-2607.
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Official URL: http://dx.doi.org/10.1016/j.cmpb.2013.06.014
Abstract
One of the major sources of information on physiological and pathophysiological effects in pre-clinical oncology studies is the xenografted tumour animal model. However, measurement of tumour volume over time potentially masks a range of biological changes that the xenograft is undergoing. In this paper a mechanistic model of tumour growth in xenografts is presented that can be used to investigate the mode of drug action with respect to phenotypic changes. The model encapsulates key histological biomarkers and spatial constraints. The unknown model parameters are first shown to be uniquely identifiable from the proposed experimental studies, and then estimated from the resulting data using the anti-cancer agent docetaxel.
Item Type: | Journal Article | ||||||||||
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Subjects: | Q Science > QA Mathematics R Medicine > RM Therapeutics. Pharmacology |
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||||||
Library of Congress Subject Headings (LCSH): | Tumors -- Growth, Xenografts | ||||||||||
Journal or Publication Title: | Computer Methods and Programs in Biomedicine | ||||||||||
Publisher: | Elsevier Ireland Ltd. | ||||||||||
ISSN: | 0169-2607 | ||||||||||
Official Date: | May 2014 | ||||||||||
Dates: |
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Volume: | Volume 114 | ||||||||||
Number: | Number 3 | ||||||||||
Number of Pages: | 11 | ||||||||||
Page Range: | e3-e13 | ||||||||||
DOI: | 10.1016/j.cmpb.2013.06.014 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||
Date of first compliant deposit: | 28 July 2016 | ||||||||||
Date of first compliant Open Access: | 28 July 2016 |
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