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Autism : reduced connectivity between cortical areas involved in face expression, theory of mind, and the sense of self
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Cheng, Wei, Rolls, Edmund T., Huaguang, Gu, Zhang, Jie and Feng, Jianfeng (2015) Autism : reduced connectivity between cortical areas involved in face expression, theory of mind, and the sense of self. Brain, 138 (Part 5). pp. 1382-1393. doi:10.1093/brain/awv051 ISSN 0006-8950.
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Official URL: http://dx.doi.org/10.1093/brain/awv051
Abstract
Whole-brain voxel-based unbiased resting state functional connectivity was analysed in 418 subjects with autism and 509 matched typically developing individuals. We identified a key system in the middle temporal gyrus/superior temporal sulcus region that has reduced cortical functional connectivity (and increased with the medial thalamus), which is implicated in face expression processing involved in social behaviour. This system has reduced functional connectivity with the ventromedial prefrontal cortex, which is implicated in emotion and social communication. The middle temporal gyrus system is also implicated in theory of mind processing. We also identified in autism a second key system in the precuneus/superior parietal lobule region with reduced functional connectivity, which is implicated in spatial functions including of oneself, and of the spatial environment. It is proposed that these two types of functionality, face expression-related, and of one’s self and the environment, are important components of the computations involved in theory of mind, whether of oneself or of others, and that reduced connectivity within and between these regions may make a major contribution to the symptoms of autism.
| Item Type: | Journal Article | ||||||||||
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| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | ||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | ||||||||||
| Library of Congress Subject Headings (LCSH): | Autism spectrum disorders, Neurophysiology, Neuropsychiatry, Social perception, Temporal lobes | ||||||||||
| Journal or Publication Title: | Brain | ||||||||||
| Publisher: | Oxford University Press | ||||||||||
| ISSN: | 0006-8950 | ||||||||||
| Official Date: | May 2015 | ||||||||||
| Dates: |
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| Volume: | 138 | ||||||||||
| Number: | Part 5 | ||||||||||
| Number of Pages: | 12 | ||||||||||
| Page Range: | pp. 1382-1393 | ||||||||||
| DOI: | 10.1093/brain/awv051 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
| Date of first compliant deposit: | 4 March 2016 | ||||||||||
| Date of first compliant Open Access: | 4 March 2016 | ||||||||||
| Funder: | Royal Society (Great Britain). Wolfson Research Merit Award (RSWRMA), Guo jia zi ran ke xue ji jin wei yuan hui (China) [National Natural Science Foundation of China] (NSFC), Hi-Tech Research and Development Program of China (HTDPC) | ||||||||||
| Grant number: | 91230201, 61271396, 11101429, 61104143, 61104224, 11471081 (NSFC), 2015AA020507 (HTDPC), 2015CB856003 |
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