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Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation
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Sun, Liang, Pitto-Barry, Anaïs, Kirby, Nigel, Schiller, Tara L., Sanchez, Ana M., Dyson, Mark Adam, Sloan, Jeremy, Wilson, Neil R., O’Reilly, Rachel K. and Dove, Andrew P. (2014) Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation. Nature Communications, Volume 5 . Article number 5746. doi:10.1038/ncomms6746 ISSN 2041-1723.
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Official URL: http://dx.doi.org/10.1038/ncomms6746
Abstract
Co-crystallization of polymers with different configurations/tacticities provides access to materials with enhanced performance. The stereocomplexation of isotactic poly(L-lactide) and poly(D-lactide) has led to improved properties compared with each homochiral material. Herein, we report the preparation of stereocomplex micelles from a mixture of poly(L-lactide)-b-poly(acrylic acid) and poly(D-lactide)-b-poly(acrylic acid) diblock copolymers in water via crystallization-driven self-assembly. During the formation of these stereocomplex micelles, an unexpected morphological transition results in the formation of dense crystalline spherical micelles rather than cylinders. Furthermore, mixture of cylinders with opposite homochirality in either THF/H2O mixtures or in pure water at 65 °C leads to disassembly into stereocomplexed spherical micelles. Similarly, a transition is also observed in a related PEO-b-PLLA/PEO-b-PDLA system, demonstrating wider applicability. This new mechanism for morphological reorganization, through competitive crystallization and stereocomplexation and without the requirement for an external stimulus, allows for new opportunities in controlled release and delivery applications.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QD Chemistry | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Physics Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) |
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Library of Congress Subject Headings (LCSH): | Polymerization, Crystallization | ||||||||
Journal or Publication Title: | Nature Communications | ||||||||
Publisher: | Nature Publishing Group | ||||||||
ISSN: | 2041-1723 | ||||||||
Official Date: | 17 December 2014 | ||||||||
Dates: |
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Volume: | Volume 5 | ||||||||
Number of Pages: | 9 | ||||||||
Article Number: | Article number 5746 | ||||||||
DOI: | 10.1038/ncomms6746 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), Warwick Centre of Analytical Sciences, Science City Research Alliance, Higher Education Funding Council for England (HEFCE), Birmingham Science City, Advantage West Midlands (AWM), European Regional Development Fund (ERDF) | ||||||||
Grant number: | EP/G004897/1 (EPSRC), EP/F034210/1 (EPSRC) |
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