The Library
Tracking the progression of bronze disease – a synchrotron X-ray diffraction study of nantokite hydrolysis
Tools
Grayburn, Rosie, Dowsett, M. G., Hand, M. (Matthew), Sabbe, Pieter-Jan, Thompson, Paul and Adriaens, Annemie (2015) Tracking the progression of bronze disease – a synchrotron X-ray diffraction study of nantokite hydrolysis. Corrosion Science, Volume 91 . pp. 220-223. doi:10.1016/j.corsci.2014.11.021 ISSN 0010-938X.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1016/j.corsci.2014.11.021
Abstract
Aims: Increases to radiotherapy dose are constrained by normal tissue effects. The relationship between bowel dose volume data and late bowel toxicity in
patients with muscle-invasive bladder cancer treated with radical radiotherapy was assessed.
Materials and methods: The bowel was contoured retrospectively on radiotherapy plans of 47 patients recruited to the BC2001 trial (CRUK/01/004). The
relationship between bowel volume at various dose levels and prospectively collected late bowel toxicity was explored.
Results: Fifteen per cent and 6% of patients experienced grade 1 and grade 2 or more late bowel toxicity, respectively. The mean bowel volume was significantly
less at doses 50 Gy in those treated with reduced high dose volume radiotherapy compared with standard radiotherapy. The probability of late bowel toxicity
increased as bowel volume increased (P 0.05 for dose levels 30e50 Gy). No grade 2 or more late bowel toxicity was observed in patients with bowel volumes
under the thresholds given in the model that predict for 25% probability of late bowel toxicity.
Conclusions: There is a dose volume effect for late bowel toxicity in radical bladder radiotherapy. We have modelled the probability of late bowel toxicity from
absolute bowel volumes to guide clinicians in assessing radical bladder radiotherapy plans. Thresholds predicting for a 25% probability of late bowel toxicity are
proposed as dose volume constraints.
Item Type: | Journal Article | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||||||||
Journal or Publication Title: | Corrosion Science | ||||||||||
Publisher: | Pergamon | ||||||||||
ISSN: | 0010-938X | ||||||||||
Official Date: | February 2015 | ||||||||||
Dates: |
|
||||||||||
Volume: | Volume 91 | ||||||||||
Page Range: | pp. 220-223 | ||||||||||
DOI: | 10.1016/j.corsci.2014.11.021 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |