The Library
Proton-counting radiography for proton therapy : a proof of principle using CMOS APS technology
Tools
Poludniowski, G, Allinson, N M, Anaxagoras, T, Esposito, M, Green, S, Manolopoulos, S, Nieto-Camero, J, Parker, D J, Price, T and Evans, P M (2014) Proton-counting radiography for proton therapy : a proof of principle using CMOS APS technology. Physics in medicine and biology, Volume 59 (Number 11). pp. 2569-2581. doi:10.1088/0031-9155/59/11/2569 ISSN 0031-9155.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1088/0031-9155/59/11/2569
Abstract
Despite the early recognition of the potential of proton imaging to assist proton therapy (Cormack 1963 J. Appl. Phys. 34 2722), the modality is still removed from clinical practice, with various approaches in development. For proton-counting radiography applications such as computed tomography (CT), the water-equivalent-path-length that each proton has travelled through an imaged object must be inferred. Typically, scintillator-based technology has been used in various energy/range telescope designs. Here we propose a very different alternative of using radiation-hard CMOS active pixel sensor technology. The ability of such a sensor to resolve the passage of individual protons in a therapy beam has not been previously shown. Here, such capability is demonstrated using a 36 MeV cyclotron beam (University of Birmingham Cyclotron, Birmingham, UK) and a 200 MeV clinical radiotherapy beam (iThemba LABS, Cape Town, SA). The feasibility of tracking individual protons through multiple CMOS layers is also demonstrated using a two-layer stack of sensors. The chief advantages of this solution are the spatial discrimination of events intrinsic to pixelated sensors, combined with the potential provision of information on both the range and residual energy of a proton. The challenges in developing a practical system are discussed.
Item Type: | Journal Article | ||||||||
---|---|---|---|---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Science > Physics Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||||||
Journal or Publication Title: | Physics in medicine and biology | ||||||||
Publisher: | IOP Publishing Ltd | ||||||||
ISSN: | 0031-9155 | ||||||||
Official Date: | 1 May 2014 | ||||||||
Dates: |
|
||||||||
Volume: | Volume 59 | ||||||||
Number: | Number 11 | ||||||||
Page Range: | pp. 2569-2581 | ||||||||
DOI: | 10.1088/0031-9155/59/11/2569 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |