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1H magnetic resonance spectroscopy in the diagnosis of paediatric low grade brain tumours
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Orphanidou-Vlachou, E., Auer, D., Brundler, M. A., Davies, N. P., Jaspan, T., MacPherson, L., Natarajan, K., Sun, Y., Arvanitis, Theodoros N., Grundy, R. G. and Peet, A. C. (2013) 1H magnetic resonance spectroscopy in the diagnosis of paediatric low grade brain tumours. European Journal of Radiology, Volume 82 (Number 6). e295-e301. doi:10.1016/j.ejrad.2013.01.030 ISSN 0720-048X.
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Official URL: http://dx.doi.org/10.1016/j.ejrad.2013.01.030
Abstract
Introduction:
Low grade gliomas are the commonest brain tumours in children but present in a myriad of ways, each with its own treatment challenges. Conventional MRI scans play an important role in their management but have limited ability to identify likely clinical behaviour. The aim of this study is to investigate 1H magnetic resonance spectroscopy (MRS) as a method for detecting differences between the various low grade gliomas and related tumours in children.
Patients and methods:
Short echo time single voxel 1H MRS at 1.5 or 3.0 T was performed prior to treatment on children with low grade brain tumours at two centres and five MR scanners, 69 cases had data which passed quality control. MRS data was processed using LCModel to give mean spectra and metabolite concentrations which were compared using T-tests, ANOVA, Receiver Operator Characteristic curves and logistic regression in SPSS.
Results:
Significant differences were found in concentrations of key metabolites between glioneuronal and glial tumours (T-test p < 0.05) and between most of the individual histological subtypes of low grade gliomas. The discriminatory metabolites identified, such as choline and myoinositol, are known tumour biomarkers. In the set of pilocytic astrocytomas and unbiopsied optic pathway gliomas, significant differences (p < 0.05, ANOVA) were found in metabolite profiles of tumours depending on location and patient neurofibromatosis type 1 status. Logistic regression analyses yielded equations which could be used to assess the probability of a tumour being of a specific type.
Conclusions:
MRS can detect subtle differences between low grade brain tumours in children and should form part of the clinical assessment of these tumours.
Item Type: | Journal Article | ||||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) | ||||||||||
Journal or Publication Title: | European Journal of Radiology | ||||||||||
Publisher: | Elsevier Ireland Ltd. | ||||||||||
ISSN: | 0720-048X | ||||||||||
Official Date: | June 2013 | ||||||||||
Dates: |
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Volume: | Volume 82 | ||||||||||
Number: | Number 6 | ||||||||||
Page Range: | e295-e301 | ||||||||||
DOI: | 10.1016/j.ejrad.2013.01.030 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access |
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