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Using constraints and their value for optimization of large ODE systems
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Domijan, Mirela and Rand, D. A. (David A.) (2015) Using constraints and their value for optimization of large ODE systems. Journal of The Royal Society Interface, Volume 12 (Number 104). Article number 20141303. doi:10.1098/rsif.2014.1303 ISSN 1742-5689.
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Official URL: http://dx.doi.org/10.1098/rsif.2014.1303
Abstract
We provide analytical tools to facilitate a rigorous assessment of the quality and value of the fit of a complex model to data. We use this to provide approaches to model fitting, parameter estimation, the design of optimization functions and experimental optimization. This is in the context where multiple constraints are used to select or optimize a large model defined by differential equations. We illustrate the approach using models of circadian clocks and the NF-κB signalling system.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QH Natural history | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Mathematics Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre |
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Library of Congress Subject Headings (LCSH): | Systems biology, Estimation theory, Circadian rhythms | ||||||||
Journal or Publication Title: | Journal of The Royal Society Interface | ||||||||
Publisher: | The Royal Society Publishing | ||||||||
ISSN: | 1742-5689 | ||||||||
Official Date: | 11 February 2015 | ||||||||
Dates: |
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Volume: | Volume 12 | ||||||||
Number: | Number 104 | ||||||||
Number of Pages: | 11 | ||||||||
Article Number: | Article number 20141303 | ||||||||
DOI: | 10.1098/rsif.2014.1303 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 29 December 2015 | ||||||||
Date of first compliant Open Access: | 29 December 2015 | ||||||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Engineering and Physical Sciences Research Council (EPSRC) | ||||||||
Grant number: | BB/F005261/1 (BBSRC), BB/F005938/1 (BBSRC), BB/K003097/1 (BBSRC), EP/C544587/1 (EPSRC) |
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