The Library
Eighteenth-century genomes show that mixed infections were common at time of peak tuberculosis in Europe
Tools
Tools
Tools
Kay, Gemma L., Sergeant, Martin J., Zhou, Zhemin, Chan, Jacqueline, Millard, Andrew D., Quick, Joshua, Szikossy, Ildikó, Pap, Ildikó, Spigelman, Mark, Loman, Nicholas J., Achtman, Mark, Donoghue, Helen D. and Pallen, Mark J. (2015) Eighteenth-century genomes show that mixed infections were common at time of peak tuberculosis in Europe. Nature Communications, Volume 6 . pp. 1-9. Article number 6717. doi:10.1038/ncomms7717
|
PDF (Creative Commons : Attribution 4.0)
WRAP_ncomms7717.pdf - Published Version - Requires a PDF viewer. Download (2063Kb) | Preview |
Official URL: http://dx.doi.org/10.1038/ncomms7717
Abstract
Tuberculosis (TB) was once a major killer in Europe, but it is unclear how the strains and patterns of infection at ‘peak TB’ relate to what we see today. Here we describe 14 genome sequences of M. tuberculosis, representing 12 distinct genotypes, obtained from human remains from eighteenth-century Hungary using metagenomics. All our historic genotypes belong to M. tuberculosis Lineage 4. Bayesian phylogenetic dating, based on samples with well-documented dates, places the most recent common ancestor of this lineage in the late Roman period. We find that most bodies yielded more than one M. tuberculosis genotype and we document an intimate epidemiological link between infections in two long-dead individuals. Our results suggest that metagenomic approaches usefully inform detection and characterization of historical and contemporary infections.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QR Microbiology R Medicine > RA Public aspects of medicine |
||||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Medicine > Warwick Medical School |
||||||||
| Library of Congress Subject Headings (LCSH): | Tuberculosis -- Microbiology, Metagenomics | ||||||||
| Journal or Publication Title: | Nature Communications | ||||||||
| Publisher: | Nature Publishing Group | ||||||||
| ISSN: | 2041-1723 | ||||||||
| Official Date: | 7 April 2015 | ||||||||
| Dates: |
|
||||||||
| Date of first compliant deposit: | 29 December 2015 | ||||||||
| Volume: | Volume 6 | ||||||||
| Number of Pages: | 9 | ||||||||
| Page Range: | pp. 1-9 | ||||||||
| Article Number: | Article number 6717 | ||||||||
| DOI: | 10.1038/ncomms7717 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
| Funder: | Warwick Medical School, Wellcome Trust (London, England), Medical Research Council (Great Britain) (MRC) | ||||||||
| Grant number: | 0516/Z/97/Z (WT) |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
