Breast Cancer Association Consortium (Including: Muir, Kenneth (Kenneth R.), Lophatananon, Artitaya and Stewart-Brown, Sarah L.). (2013) FGF receptor genes and breast cancer susceptibility : results from the Breast Cancer Association Consortium. British Journal of Cancer, Volume 110 (Number 4). pp. 1088-1100. doi:10.1038/bjc.2013.769 ISSN 0007-0920.

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Abstract

Background: Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.

Methods: Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.

Results: Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02–1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2.

Conclusion: Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Breast -- Cancer -- Susceptibility, Breast -- Cancer -- Genetic aspects
Journal or Publication Title:	British Journal of Cancer
Publisher:	Nature Publishing Group
ISSN:	0007-0920
Official Date:	15 November 2013
Dates:	Date Event 18 February 2014 Modified 15 November 2013 Accepted 4 September 2013 Submitted
Volume:	Volume 110
Number:	Number 4
Page Range:	pp. 1088-1100
DOI:	10.1038/bjc.2013.769
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Date of first compliant deposit:	29 December 2015
Date of first compliant Open Access:	29 December 2015
Funder:	Cancer Research UK (CRUK), Seventh Framework Programme (European Commission) (FP7), European Union (EU), Canadian Institutes of Health Research (CIHR), Québec (Province). Ministry of Economic Development, Innovation and Export Trade, National Institutes of Health (U.S.) (NIH), National Cancer Institute (U.S.) (NCI), United States. Department of Defense (DoD), Susan G. Komen for the Cure, Breast Cancer Research Foundation, Ovarian Cancer Research Fund, National Health and Medical Research Council (Australia) (NHMRC) , New South Wales State Cancer Council, Victorian Health Promotion Foundation (VHPF), Victorian Breast Cancer Research Consortium, KWF Kankerbestrijding [Dutch Cancer Society], Breast Cancer Research Trust (Great Britain), Universitätsklinikum Erlangen, Breakthrough Breast Cancer, National Institute for Health Research (Great Britain) (NIHR), Oxford Biomedical Research Centre, Dietmar Hopp Stiftung, Hermann von Helmholtz-Gemeinschaft Deutscher Forschungszentren (HGF), German Cancer Research Center, Fondation de France (FF), Institut National Du Cancer (France), Ligue nationale contre le cancer (France) (LNCC), French agency for Food, Environmental and Occupational Health Safety (ANSES), France. Agence nationale de la recherche (ANR), Fondation ARC pour la Recherche sur le Cancer, Chief Physician Johan Boserup and Lise Boserup's Fund, Statens lægevidenskabelige forskningsråd (Denmark) [Danish Medical Research Council] (SLF), Herlev Hospital [Denmark], Genome Spain Foundation, Red Temática de investigación cooperativa en cáncer, Asociación Española contra el Cáncer, Fondo de Investigaciones Sanitarias (Spain), Instituto de Salud Carlos III, Michael Manzella Foundation, California Breast Cancer Research Program, Lon V Smith Foundation, Baden-Württemberg (Germany). Ministerium für Wissenschaft, Forschung und Kunst, Deutsche Krebshilfe [German Cancer Aid], Germany. Bundesministerium für Bildung und Forschung (BMBF), Robert Bosch Stiftung, Deutsches Krebsforschungszentrum Heidelberg (DKFZ), Ruhr-Universität Bochum. Institut für Prävention und Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung, Johanniter-Krankenhaus Bonn. Abteilung Innere Medizin, Helsingin yliopistollinen keskussairaala [Helsinki University Central Hospital], Suomen Akatemia [Academy of Finland], Suomen Syöpäyhdistys [Cancer Society of Finland], Nordic Cancer Union, Sigrid Jusélius stiftelse, Japan. Monbu Kagakushō [Japan. Ministry of Education, Culture, Sports, Science and Technology] (MK), Japan. Kōsei Rōdōshō [Japan. Ministry of Health, Labour and Welfare], Takeda Kagaku Shinkō Zaidan [Takeda Science Foundation], Kokuritsu Gan Sentā [Japan. National Cancer Center], Deutscher Akademischer Austauschdienst (DAAD), Friends of Hannover Medical School, Stockholms län (Sweden). Landstinget, Karolinska institutet, Stockholm Cancer Foundation, Cancerfonden, Kuopion yliopistollinen Keskussairaala (Finland) [Kuopio University Hospital], Cancer Fund of North Savo, Itä-Suomen yliopisto [University of Eastern Finland], National Breast Cancer Foundation, Queensland Cancer Fund, Cancer Council Victoria, Cancer Council Tasmania, Cancer Council South Australia, Cancer Foundation of Western Australia, United States. Army Medical Research and Materiel Command (DAMD), California. Department of Health, Stichting tegen Kanker (Belgium), Hamburg Cancer Society, Associazione italiana per la ricerca sul cancro, David F and Margaret T Grohne Family Foundation, Ting Tsung and Wei Fong Chao Foundation, Quebec Breast Cancer Foundation, Malaysia. Kementerian Sains, Teknologi dan Inovasi (MOTSI), Malaysia. Kementerian Pengajian Tinggi [Malaysia. Ministry of Higher Education], Cancer Research Initiatives Foundation (CARIF), Singapore. Biomedical Research Council, Singapore. National Medical Research Council, Norges forskningsråd [Norwegian Research Council], Oulun yliopisto [University of Oulu], Oulun yliopistollinen sairaala (OYS), Biobanking and Biomolecular Resources Research Infrastructure (BBMRI), Marit and Hans Rausing initiative against breast cancer, Sweden. Vetenskapsrådet [Research Council], Singapore. Agency for Science, Technology and Research (ASTAR), Riksföreningen mot cancer [Swedish Cancer Society], Yorkshire Cancer Research Campaign, National Program of Cancer Registries (U.S.), Fundacja na rzecz Nauki Polskiej [Foundation for Polish Science] (FNP), Ohio State University. Comprehensive Cancer Center, Stefanie Spielman Fund for Breast Cancer Research, Greece. General Secretariat of Research and Technology, Zhong yang yan jiu yuan [Academia Sinica (Taipei, Taiwan)], Guo jia ke xue wei yuan hui [National Science Council (Taiwan)], Institute of Cancer Research (London, England)
Grant number:	C1287/A10118 (CRUK), C1287/A12014 (CRUK), 223175 (FP7), BM0606 (EU), C1287/A10710 (CRUK), PSR-SIIRI-701 (MEDIET), CA128978 (NIH), 1U19 CA148537 (NCI), 1U19 CA148065 (NCI), 1U19 CA148112 (NCI), W81XWH-10-1-0341 (DoD), UM1 CA164920 (NCI), NKI2007-3839 (KWF)

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