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Mathematical models of human African trypanosomiasis epidemiology
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Rock, Kat S., Stone, Chris M., Hastings, Ian M., Keeling, Matthew James, Torr, Stephen J. and Chitnis, Nakul (2015) Mathematical models of human African trypanosomiasis epidemiology. In: Mathematical Models for Neglected Tropical Diseases: Essential Tools for Control and Elimination, Part A. Academic Press, pp. 53-133.
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Official URL: http://dx.doi.org/10.1016/bs.apar.2014.12.003
Abstract
Human African trypanosomiasis (HAT), commonly called sleeping sickness, is caused by Trypanosoma spp. and transmitted by tsetse flies (Glossina spp.). HAT is usually fatal if untreated and transmission occurs in foci across sub-Saharan Africa. Mathematical modelling of HAT began in the 1980s with extensions of the Ross–Macdonald malaria model and has since consisted, with a few exceptions, of similar deterministic compartmental models. These models have captured the main features of HAT epidemiology and provided insight on the effectiveness of the two main control interventions (treatment of humans and tsetse fly control) in eliminating transmission. However, most existing models have overestimated prevalence of infection and ignored transient dynamics. There is a need for properly validated models, evolving with improved data collection, that can provide quantitative predictions to help guide control and elimination strategies for HAT.
| Item Type: | Book Item | ||||||
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| Subjects: | Q Science > QL Zoology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) Faculty of Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | African trypanosomiasis -- Mathematical models, Trypanosomiasis in animals, Africa, Sub-Saharan -- Health aspects, Tsetse-flies , Parasitic diseases -- Prevention | ||||||
| Journal or Publication Title: | Advances in Parasitology | ||||||
| Publisher: | Academic Press | ||||||
| ISSN: | 0065-308X | ||||||
| Book Title: | Mathematical Models for Neglected Tropical Diseases: Essential Tools for Control and Elimination, Part A | ||||||
| Official Date: | March 2015 | ||||||
| Dates: |
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| Date of first compliant deposit: | 6 June 2016 | ||||||
| Volume: | Volume 87 | ||||||
| Page Range: | pp. 53-133 | ||||||
| DOI: | 10.1016/bs.apar.2014.12.003 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||
| Funder: | Engineering and Physical Sciences Research Council (EPSRC), Bill & Melinda Gates Foundation, Research and Policy for Infectious Disease Dynamics Program, Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) | ||||||
| Grant number: | OPP1037660 (Bill & Melinda Gates Foundation) |
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