The Library
Increased DNA dicarbonyl glycation and oxidation markers in patients with type 2 diabetes and link to diabetic nephropathy
Tools
Tools
Tools
Waris, Sahar, Winklhofer-Roob, Brigitte M., Roob, Johannes, M., Fuchs, Sebastian W., Souriji, Harald, Rabbani, Naila and Thornalley, Paul J. (2015) Increased DNA dicarbonyl glycation and oxidation markers in patients with type 2 diabetes and link to diabetic nephropathy. Journal of Diabetes Research, Volume 2015 . Article number 915486. doi:10.1155/2015/915486 ISSN 2314-6745.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1155/2015/915486
Abstract
Aim. The aim of this study was to assess the changes of markers of DNA damage by glycation and oxidation in patients with type 2 diabetes and the association with diabetic nephropathy. Methodology. DNA oxidation and glycation adducts were analysed in plasma and urine by stable isotopic dilution analysis liquid chromatography-tandem mass spectrometry. DNA markers analysed were as follows: the oxidation adduct 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-OxodG) and glycation adducts of glyoxal and methylglyoxal—imidazopurinones GdG, MGdG, and N2-(1,R/S-carboxyethyl)deoxyguanosine (CEdG). Results. Plasma 8-OxodG and GdG were increased 2-fold and 6-fold, respectively, in patients with type 2 diabetes, with respect to healthy volunteers. Median urinary excretion rates of 8-OxodG, GdG, MGdG, and CEdG were increased 28-fold, 10-fold, 2-fold, and 2-fold, respectively, in patients with type 2 diabetes with respect to healthy controls. In patients with type 2 diabetes, nephropathy was associated with increased plasma 8-OxodG and increased urinary GdG and CEdG. In a multiple logistic regression model for diabetic nephropathy, diabetic nephropathy was linked to systolic blood pressure and urinary CEdG. Conclusion. DNA oxidative and glycation damage-derived nucleoside adducts are increased in plasma and urine of patients with type 2 diabetes and further increased in patients with diabetic nephropathy.
| Item Type: | Journal Article | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine |
||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||||||||
| Library of Congress Subject Headings (LCSH): | Non-insulin-dependent diabetes, Diabetic nephropathies , DNA damage, Glycosylation, Oxidation | ||||||||||
| Journal or Publication Title: | Journal of Diabetes Research | ||||||||||
| Publisher: | Hindawi Publishing Corporation | ||||||||||
| ISSN: | 2314-6745 | ||||||||||
| Official Date: | 1 January 2015 | ||||||||||
| Dates: |
|
||||||||||
| Volume: | Volume 2015 | ||||||||||
| Number of Pages: | 10 | ||||||||||
| Article Number: | Article number 915486 | ||||||||||
| DOI: | 10.1155/2015/915486 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
| Funder: | Commonwealth Scholarship Commission in the United Kingdom (CSCUK), Sixth Framework Programme (European Commission) (FP6), Fifth Framework Programme (European Commission) (FP5) | ||||||||||
| Grant number: | PIN 202002 (CSCUK), LSHM-CT-2005-018733 PREDICTIONS (FP6), QLK1-CT-1999-00830 VITAGE (FP5) |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
