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Nesfatin-1 inhibits proliferation and enhances apoptosis of human adrenocortical H295R cells
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Ramanjaneya, Manjunath, Tan, Bee K., Rucinski, R., Kawan, Mohamed, Hu, Jiamiao, Kaur, Jaspreet, Patel, Vanlata H., Malendowicz, L. K. , Komarowska, H., Lehnert, Hendrik and Randeva, Harpal S. (2015) Nesfatin-1 inhibits proliferation and enhances apoptosis of human adrenocortical H295R cells. Journal of Endocrinology, Volume 226 (Number 1). pp. 1-11. doi:10.1530/JOE-14-0496 ISSN 0022-0795.
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Official URL: http://dx.doi.org/10.1530/JOE-14-0496
Abstract
NUCB2/nesfatin and its proteolytically cleaved product nesfatin-1 are recently discovered anorexigenic hypothalamic neuroproteins involved in energy homeostasis. It is expressed both centrally and in peripheral tissues, and appears to have potent metabolic actions. NUCB2/nesfatin neurons are activated in response to stress. Central nesfatin-1 administration elevates circulating ACTH and corticosterone levels. Bilateral adrenalectomy increased NUCB2/nesfatin mRNA levels in rat paraventricular nuclei. To date, studies have not assessed the effects of nesfatin-1 stimulation on human adrenocortical cells. Therefore, we investigated the expression and effects of nesfatin-1 in a human adrenocortical cell model (H295R). Our findings demonstrate that NUCB2 and nesfatin-1 are expressed in human adrenal gland and human adrenocortical cells (H295R). Stimulation with nesfatin-1 inhibits the growth of H295R cells and promotes apoptosis, potentially via the involvement of Bax, BCL-XL and BCL-2 genes as well as ERK1/2, p38 and JNK1/2 signalling cascades. This has implications for understanding the role of NUCB2/nesfatin in adrenal zonal development. NUCB2/nesfatin may also be a therapeutic target for adrenal cancer. However, further studies using in vivo models are needed to clarify these concepts.
| Item Type: | Journal Article | ||||||||||
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| Subjects: | Q Science > QP Physiology | ||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > ( - July 2016) Medical Education Hub Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Nerve tissue proteins -- Research, Homeostasis , Metabolism -- Endocrine aspects | ||||||||||
| Journal or Publication Title: | Journal of Endocrinology | ||||||||||
| Publisher: | Society for Endocrinology | ||||||||||
| ISSN: | 0022-0795 | ||||||||||
| Official Date: | July 2015 | ||||||||||
| Dates: |
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| Volume: | Volume 226 | ||||||||||
| Number: | Number 1 | ||||||||||
| Page Range: | pp. 1-11 | ||||||||||
| DOI: | 10.1530/JOE-14-0496 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Open Access (Creative Commons) |
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