Mohammad, R., Mashlah, A., Abou-Hamed, H. and Abou-Rabii, I. (2014) Salivary flow among patients with minor recurrent Aphthous Stomatitis. Journal of Dental Research, 93 (Special issue B). 226. ISSN 0022-0345.

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Abstract

Objective:
Recurrent aphthous stomatitis (RAS) is a common oral mucosal disease that despite plenty of studies on it, its aetiopathogenesis is still unclear.

The aim of this study was to investigate any potential changes of the whole unstimulated salivary flow rate among RAS patients, hence, a probable role of quantitative saliva changes in the course of RAS may be discovered.

Method:

The whole unstimulated salivary rate was measured using passive drooling method in 41 minor RAS patients in both acute (the presence of active ulcer(s) that has/have appeared no more than 72 hours) and remission phases (After one week of complete healing of ulcer(s)) of the disease. Patients were followed in a monthly basis for one year, and information related to the recurrence rate and the number of active ulcers were obtained and recorded. Data were entered in SPSS software version 19, then analyzed using Independent t-test, Paired t-test, and Pearson Correlation coefficient at significance level of 0.05.

Result:

No significant difference was noticed regarding the whole unstimulated salivary flow rate between patients (Mean=0.56 ml/min, SD=0.14) and healthy controls (Mean=0.54 ml/min, SD= 0.12, P>0.05), or in patients themselves between the two phases of the disease (Mean acute = 0.61 ml/min, SD= 0.18, Mean remission =0.56ml/min, SD=0.14, P>0.05). However, there was a statistically significant positive correlation between salivary flow rate; and both recurrence rate (r=0.32, P<0.05), and the average number of accompanying ulcers (r=0.41, P<0.05).

Conclusion:

Quantitative changes in saliva don't seem to play a role in the course of minor RAS. However, severe cases of minor RAS, which are characterised by the presence of more than two ulcers in a single attack and a very frequent recurrence, may be accompanied by higher saliva production which may represent a reactive response towards the active presence of RAS ulcers in the mouth.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > ( - July 2016) Medical Education Hub Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title:	Journal of Dental Research
Publisher:	Sage Publications, Inc.
ISSN:	0022-0345
Official Date:	January 2014
Dates:	Date Event January 2014 Published
Volume:	93
Number:	Special issue B
Article Number:	226
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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