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The structure of cross-β tapes and tubes formed by an octapeptide, αSβ1
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Morris, Kyle L., Zibaee, Shahin, Chen, Lin, Goedert, Michel, Sikorski, Pawel and Serpell, Louise C. (2013) The structure of cross-β tapes and tubes formed by an octapeptide, αSβ1. Angewandte Chemie International Edition, 52 (8). pp. 2279-2283. doi:10.1002/anie.201207699 ISSN 1521-3773.
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WRAP_Morris_et_al-2013-Angewandte_Chemie_International_Edition.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (2745Kb) | Preview |
Official URL: http://dx.doi.org/10.1002/anie.201207699
Abstract
A number of short peptides and larger proteins are able to self-assemble to form cross-b amyloid-like fibrils.[1] These bsheet peptides have been increasingly explored as potentially useful bionanomaterials due to their propensity to spontaneously assemble to form large complex structures from simple monomers.[2] An eight-residue fragment of the amyloidogenic Parkinsons disease related peptide a-synuclein,[3] named aSb1, assembles to form a helical nanostructure. Here we report the supramolecular and molecular architecture of these helical nanotubes. The supramolecular structure consists of two peptide molecules forming an amphiphilic bilayer that extends into a tape, which subsequently adopts a helical arrangement that closes to form the nanotube morphology. The structural model is proposed based on interpretation of fiber diffraction data from nanotube samples with two different textures. Analysis reveals a cross-b structure within the tapes, which go on to form an elaborate cross-b nanotubular architecture.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QR Microbiology R Medicine > RC Internal medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
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Library of Congress Subject Headings (LCSH): | Multiple system atrophy, Peptide amphiphiles -- Formation, Nanotubes | ||||||||
Journal or Publication Title: | Angewandte Chemie International Edition | ||||||||
Publisher: | Wiley-Blackwell Publishing, Inc. | ||||||||
ISSN: | 1521-3773 | ||||||||
Official Date: | 13 February 2013 | ||||||||
Dates: |
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Volume: | 52 | ||||||||
Number: | 8 | ||||||||
Number of Pages: | 5 | ||||||||
Page Range: | pp. 2279-2283 | ||||||||
DOI: | 10.1002/anie.201207699 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 22 March 2016 | ||||||||
Date of first compliant Open Access: | 22 March 2016 | ||||||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Medical Research Council (Great Britain) (MRC), Multiple System Atrophy Trust, Alzheimer's Research Trust | ||||||||
Grant number: | U105184291 (MRC) |
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