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Metformin increases the novel adipokine adipolin/CTRP12 : role of the AMPK pathway
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Tan, Bee K., Chen, Jing, Adya, Raghu, Ramanjaneya, Manjunath, Patel, Vanlata H. and Randeva, Harpal S. (2013) Metformin increases the novel adipokine adipolin/CTRP12 : role of the AMPK pathway. Journal of Endocrinology, Volume 219 (Number 2). pp. 101-108. doi:10.1530/JOE-13-0277 ISSN 0022-0795.
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Official URL: http://dx.doi.org/10.1530/JOE-13-0277
Abstract
Adipolin is a novel adipokine with anti-inflammatory and glucose-lowering properties. Lower levels of adipolin are found in obese and diabetic mice. Polycystic ovary syndrome (PCOS) is a pro-inflammatory state associated with obesity and diabetes. To date, there are no human studies on adipolin. Therefore, we measured serum (ELISA) and adipose tissue adipolin mRNA expression (RT-PCR) and protein concentrations (western blotting) in PCOS and control subjects. We also investigated the ex vivo effect of glucose and metformin on adipolin protein production in human subcutaneous adipose tissue explants. We report novel data that serum and subcutaneous adipose tissue adipolin mRNA expression and protein concentrations were significantly lower in women with PCOS compared with control subjects. Furthermore, Spearman's rank analysis showed that serum adipolin concentrations were significantly negatively correlated with BMI, waist-to-hip ratio, and glucose (P<0.05). However, when subjected to multiple regression analysis, none of these variables were predictive of serum adipolin concentrations (P>0.05). Also, subcutaneous adipose tissue adipolin mRNA expression and protein concentrations were only significantly negatively correlated with glucose (P<0.05). No significant correlations were found with omental adipose tissue adipolin mRNA expression and protein concentrations (P>0.05). Moreover, glucose profoundly reduced and metformin significantly increased adipolin protein production in human adipose tissue explants respectively. Importantly, metformin's effects appear to be via the AMP-activated protein kinase signaling pathway.
| Item Type: | Journal Article | ||||||||
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| Subjects: | R Medicine > RC Internal medicine | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Adipose tissues -- Endocrine aspects, Metformin , Diabetes , Polycystic ovary syndrome -- Endocrine aspects. | ||||||||
| Journal or Publication Title: | Journal of Endocrinology | ||||||||
| Publisher: | Society for Endocrinology | ||||||||
| ISSN: | 0022-0795 | ||||||||
| Official Date: | 4 October 2013 | ||||||||
| Dates: |
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| Volume: | Volume 219 | ||||||||
| Number: | Number 2 | ||||||||
| Page Range: | pp. 101-108 | ||||||||
| DOI: | 10.1530/JOE-13-0277 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) |
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