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Neuroendocrine and endocrine dysfunction in the hyperinsulinemic PCOS patient : the role of metformin
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Weickert, Martin O., Hodges, P., Tan, Bee K. and Randeva, Harpal S. (2012) Neuroendocrine and endocrine dysfunction in the hyperinsulinemic PCOS patient : the role of metformin. Minerva endocrinologica, Volume 37 (Number 1). pp. 25-40. ISSN 0391-1977.
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Abstract
Metformin is a widely used and extensively studied insulin sensitising drug for the treatment of women with polycystic ovary syndrome (PCOS), with various actions in tissues responding to insulin that include the liver, skeletal muscle, adipose tissue, the endothelium of blood vessels, and the ovaries. Treatment of PCOS women with metformin has been shown to reduce fasting glucose levels, blood pressure, and serum androgens; further effects of metformin in women with PCOS may include direct effects on the central nervous system; and indirect effects via the modification of gut hormone and adipokine synthesis and/or secretion. A number of "novel" adipokines and metabolic factors have been recently identified which may play a role both in the pathogenesis and the treatment of women with PCOS. We here discuss recent advances in the area, with a focus on neuroendocrine and endocrine dysfunctions in women with PCOS and the potential role of metformin in this context.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Minerva endocrinologica | ||||
| Publisher: | Edizioni Minerva Medica | ||||
| ISSN: | 0391-1977 | ||||
| Official Date: | March 2012 | ||||
| Dates: |
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| Volume: | Volume 37 | ||||
| Number: | Number 1 | ||||
| Page Range: | pp. 25-40 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Related URLs: |
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