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Optimization of the polymer coating for glycosylated gold nanoparticle biosensors to ensure stability and rapid optical readouts
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Richards, Sarah-Jane and Gibson, Matthew I. (2014) Optimization of the polymer coating for glycosylated gold nanoparticle biosensors to ensure stability and rapid optical readouts. ACS Macro Letters, 3 (10). pp. 1004-1008. doi:10.1021/mz5004882 ISSN 2161-1653.
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Official URL: http://dx.doi.org/10.1021/mz5004882
Abstract
The development of new analytical tools to probe pathogenic infection processes and as point-of-care biosensors is crucial to combat the spread of infectious diseases or to detect biological warfare agents. Glycosylated gold nanoparticles that change color due to lectin (carbohydrate-binding protein) mediated aggregation may find use as biosensors but require a polymer coating between the particle surface and sugar to ensure stability in complex media. Here, RAFT polymerization is employed to generate glycosylated polymers to coat gold nanoparticles. Rather than being a passive component, it is shown here that the polymer coating has to be precisely tuned to achieve a balance between saline (steric) stability and speed of the readout. If the polymer is too long it can prevent or slow aggregation and hence lead to a poor readout in sensing assays. The optimized glyco-nanoparticles are also demonstrated to be useful for rapid detection of a ricin surrogate.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry R Medicine > RC Internal medicine U Military Science > U Military Science (General) |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Polymers, Gold, Nanoparticles, Biosensors , Communicable diseases -- Prevention, Biological weapons -- Identification, Glycomics | ||||
Journal or Publication Title: | ACS Macro Letters | ||||
Publisher: | American Chemical Society | ||||
ISSN: | 2161-1653 | ||||
Official Date: | 16 September 2014 | ||||
Dates: |
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Volume: | 3 | ||||
Number: | 10 | ||||
Page Range: | pp. 1004-1008 | ||||
DOI: | 10.1021/mz5004882 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Funder: | Advantage West Midlands (AWM), European Regional Development Fund (ERDF), Birmingham Science City, Higher Education Funding Council for England (HEFCE), Engineering and Physical Sciences Research Council (EPSRC) |
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