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Isothermally-responsive polymers triggered by selective binding of Fe3+to siderophoric catechol end-groups
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Phillips, Daniel J., Prokes, Ivan, Davies, Gemma L. and Gibson, Matthew I. (2014) Isothermally-responsive polymers triggered by selective binding of Fe3+to siderophoric catechol end-groups. ACS Macro Letters, 3 (12). pp. 1225-1229. doi:10.1021/mz500686w ISSN 2161-1653.
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Official URL: http://dx.doi.org/10.1021/mz500686w
Abstract
Thermoresponsive polymers have attracted huge interest as a way of developing smart/adaptable materials for biomedicine, particularly due to changes in their solubility above the LCST. However, temperature is not always an appropriate or desirable stimulus given the variety of other cellular microenvironments that exist, including pH, redox potentials, ionic strength, and metal ion concentration. Here, we achieve a highly specific, isothermal solubility switch for poly(N-isopropylacrylamide) by application of ferric iron (Fe3+), a species implicated in a range of neurodegenerative conditions. This is achieved by the site-specific incorporation of (Fe3+-binding) catechol units onto the polymer chain-end, inspired by the mechanism by which bacterial siderophores sequester iron from mammalian hosts. The ability to manipulate the hydrophilicity of responsive systems without the need for a temperature gradient offers an exciting approach toward preparing increasingly selective, targeted polymeric materials.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry R Medicine > R Medicine (General) |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
| Library of Congress Subject Headings (LCSH): | Thermoresponsive polymers, Nervous system -- Degeneration -- Research, Polymers in medicine, Biomedical materials | ||||
| Journal or Publication Title: | ACS Macro Letters | ||||
| Publisher: | American Chemical Society | ||||
| ISSN: | 2161-1653 | ||||
| Official Date: | 13 October 2014 | ||||
| Dates: |
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| Volume: | 3 | ||||
| Number: | 12 | ||||
| Page Range: | pp. 1225-1229 | ||||
| DOI: | 10.1021/mz500686w | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Advantage West Midlands (AWM), European Regional Development Fund (ERDF), University of Warwick Institute of Advanced Study Scholarship, Royal Society (Great Britain), University of Warwick. Medical And Life Sciences Research Fund, General Charities of the City of Coventry (GCCC) |
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