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Siderophore-inspired nanoparticle-based biosensor for the selective detection of Fe3+

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Phillips, Daniel J., Davies, Gemma L. and Gibson, Matthew I. (2015) Siderophore-inspired nanoparticle-based biosensor for the selective detection of Fe3+. Journal of Materials Chemistry B, 3 (2). pp. 270-275. doi:10.1039/c4tb01501k ISSN 2050-750X.

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Official URL: http://dx.doi.org/10.1039/C4TB01501K

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Abstract

Inspired by nature's exploitation of the 1,2-dihydroxybenzene unit (or catechol) in mammalian and bacterial siderophores, we report the first example of a nanoparticle sensing system that utilises the strong catechol–Fe3+ binding motif to trigger nanoparticle aggregation, promoting a powerful optical response. Gold nanoparticles are functionalised with RAFT polymerisation-prepared water-soluble poly(N-hydroxyethyl acrylamide) containing a catechol moiety at the α-chain-end. A strong red-to-purple colorimetric response occurs in the presence of Fe3+ at serum concentrations (8–25 μM) in saline solution. Sodium chloride is critical in generating a strong optical output, as is the length of polymer used to coat the AuNPs. This behaviour is also demonstrated to be selective for Fe3+ over a host of other biologically relevant ions.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology
R Medicine > R Medicine (General)
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH): Siderophores, Biosensors , Nanoparticles, Gold
Journal or Publication Title: Journal of Materials Chemistry B
Publisher: R S C Publications
ISSN: 2050-750X
Official Date: 14 January 2015
Dates:
DateEvent
14 January 2015Published
7 November 2014Available
5 November 2014Accepted
10 September 2014Submitted
Volume: 3
Number: 2
Page Range: pp. 270-275
DOI: 10.1039/c4tb01501k
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Advantage West Midlands (AWM), European Regional Development Fund (ERDF), Birmingham Science City, Higher Education Funding Council for England (HEFCE), University of Warwick Postgraduate Research Scholarship, University of Warwick. Institute of Advanced Study (IAS), University of Warwick. Medical And Life Sciences Research Fund, General Charities of the City of Coventry (GCCC)
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