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Siderophore-inspired nanoparticle-based biosensor for the selective detection of Fe3+
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Phillips, Daniel J., Davies, Gemma L. and Gibson, Matthew I. (2015) Siderophore-inspired nanoparticle-based biosensor for the selective detection of Fe3+. Journal of Materials Chemistry B, 3 (2). pp. 270-275. doi:10.1039/c4tb01501k
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Official URL: http://dx.doi.org/10.1039/C4TB01501K
Abstract
Inspired by nature's exploitation of the 1,2-dihydroxybenzene unit (or catechol) in mammalian and bacterial siderophores, we report the first example of a nanoparticle sensing system that utilises the strong catechol–Fe3+ binding motif to trigger nanoparticle aggregation, promoting a powerful optical response. Gold nanoparticles are functionalised with RAFT polymerisation-prepared water-soluble poly(N-hydroxyethyl acrylamide) containing a catechol moiety at the α-chain-end. A strong red-to-purple colorimetric response occurs in the presence of Fe3+ at serum concentrations (8–25 μM) in saline solution. Sodium chloride is critical in generating a strong optical output, as is the length of polymer used to coat the AuNPs. This behaviour is also demonstrated to be selective for Fe3+ over a host of other biologically relevant ions.
| Item Type: | Journal Article | ||||||||||
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| Subjects: | Q Science > QR Microbiology R Medicine > R Medicine (General) |
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| Divisions: | Faculty of Science > Chemistry | ||||||||||
| Library of Congress Subject Headings (LCSH): | Siderophores, Biosensors , Nanoparticles, Gold | ||||||||||
| Journal or Publication Title: | Journal of Materials Chemistry B | ||||||||||
| Publisher: | R S C Publications | ||||||||||
| ISSN: | 2050-750X | ||||||||||
| Official Date: | 14 January 2015 | ||||||||||
| Dates: |
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| Volume: | 3 | ||||||||||
| Number: | 2 | ||||||||||
| Page Range: | pp. 270-275 | ||||||||||
| DOI: | 10.1039/c4tb01501k | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||
| Funder: | Advantage West Midlands (AWM), European Regional Development Fund (ERDF), Birmingham Science City, Higher Education Funding Council for England (HEFCE), University of Warwick Postgraduate Research Scholarship, University of Warwick. Institute of Advanced Study (IAS), University of Warwick. Medical And Life Sciences Research Fund, General Charities of the City of Coventry (GCCC) | ||||||||||
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