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Towards being genuinely smart : ‘isothermally-responsive’ polymers as versatile, programmable scaffolds for biologically-adaptable materials

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Phillips, Daniel J. and Gibson, Matthew I. (2015) Towards being genuinely smart : ‘isothermally-responsive’ polymers as versatile, programmable scaffolds for biologically-adaptable materials. Polymer chemistry, 6 (7). pp. 1033-1043. doi:10.1039/c4py01539h ISSN 1759-9954.

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Official URL: http://dx.doi.org/10.1039/C4PY01539H

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Abstract

Responsive polymers have found diverse application across polymer, biomaterials, medical, sensing and engineering fields. Despite many years of study, this has focussed mainly on those polymers which undergo thermally-induced changes – either a lower or upper critical solution temperature. To rival the adaptability of Nature's macromolecules, polymers must respond in a ‘smarter’ way to other triggers such as enzymes, biochemical gradients, ion concentration or metabolites, to name a few. Here we review the concept of ‘isothermal’ responses where core thermoresponsive polymers are chemically engineered such that they undergo their useful response (such as coil-globule transition, cell uptake or cargo release) but at constant temperature. This is achieved by consideration of their phase diagram where solubility can be changed by small structural changes to the end-group, side-chain/substituents or through main chain modification/binding. The current state-of-the-art is summarised here.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Smart materials
Journal or Publication Title: Polymer chemistry
Publisher: Royal Society of Chemistry
ISSN: 1759-9954
Official Date: 21 February 2015
Dates:
DateEvent
21 February 2015Published
5 December 2014Available
5 December 2014Accepted
11 November 2014Submitted
Volume: 6
Number: 7
Number of Pages: 11
Page Range: pp. 1033-1043
DOI: 10.1039/c4py01539h
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 30 December 2015
Date of first compliant Open Access: 30 December 2015
Funder: Birmingham Science City, Higher Education Funding Council for England (HEFCE), University of Warwick Postgraduate Research Scholarship

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