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Calmodulin as a major calcium buffer shaping vesicular release and short-term synaptic plasticity : facilitation through buffer dislocation
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Timofeeva, Yulia and Volynsk, Kirill E. (2015) Calmodulin as a major calcium buffer shaping vesicular release and short-term synaptic plasticity : facilitation through buffer dislocation. Frontiers in Cellular Neuroscience, 9 . pp. 1-13. 239. doi:10.3389/fncel.2015.00239 ISSN 1662-5102.
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Official URL: http://dx.doi.org/10.3389/fncel.2015.00239
Abstract
Action potential-dependent release of synaptic vesicles and short-term synaptic plasticity are dynamically regulated by the endogenous Ca2+ buffers that shape [Ca2+] profiles within a presynaptic bouton. Calmodulin is one of the most abundant presynaptic proteins and it binds Ca2+ faster than any other characterized endogenous neuronal Ca2+ buffer. Direct effects of calmodulin on fast presynaptic Ca2+ dynamics and vesicular release however have not been studied in detail. Using experimentally constrained three-dimensional diffusion modeling of Ca2+ influx–exocytosis coupling at small excitatory synapses we show that, at physiologically relevant concentrations, Ca2+ buffering by calmodulin plays a dominant role in inhibiting vesicular release and in modulating short-term synaptic plasticity. We also propose a novel and potentially powerful mechanism for short-term facilitation based on Ca2+-dependent dynamic dislocation of calmodulin molecules from the plasma membrane within the active zone.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QR Microbiology | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Research Centres > Centre for Complexity Science Faculty of Science, Engineering and Medicine > Science > Computer Science |
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| Library of Congress Subject Headings (LCSH): | Synaptic vesicles, Neuropeptides | ||||||||
| Journal or Publication Title: | Frontiers in Cellular Neuroscience | ||||||||
| Publisher: | Frontiers Research Foundation | ||||||||
| ISSN: | 1662-5102 | ||||||||
| Official Date: | 1 July 2015 | ||||||||
| Dates: |
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| Volume: | 9 | ||||||||
| Number of Pages: | 13 | ||||||||
| Page Range: | pp. 1-13 | ||||||||
| Article Number: | 239 | ||||||||
| DOI: | 10.3389/fncel.2015.00239 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 30 December 2015 | ||||||||
| Date of first compliant Open Access: | 30 December 2015 | ||||||||
| Funder: | Wellcome Trust (London, England), National Institutes of Health (U.S.) (NIH), National Institute of General Medical Sciences (U.S.) (NIGMS) | ||||||||
| Grant number: | GM103313 (NIH) | ||||||||
| Open Access Version: |
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